Details of Host Protein

KEGG: hsa00071 Pathway Download ×

KEGG: hsa00280 Pathway Download ×

KEGG: hsa01100 Pathway Download ×

KEGG: hsa01212 Pathway Download ×

KEGG: hsa00062 Pathway Download ×

Host Protein General Information (ID: PT0062)
Protein Name	3-ketoacyl-CoA thiolase (ACAA2)	Gene Name	ACAA2
Host Species	Homo sapiens	Uniprot Entry Name	THIM_HUMAN
Protein Families	Thiolase-like superfamily
EC Number	2.3.1.16; 2.3.1.9; 3.1.2.-; 3.1.2.1; 3.1.2.2
Subcellular Location	Mitochondrion
External Link
	NCBI Gene ID	10449
	Uniprot ID	P42765
	Ensembl ID	ENSG00000167315
	HGNC ID	HGNC:83
Function in Host	In the production of energy from fats, this is one of theenzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids intoacetyl-CoA. Using free coenzyme A/CoA, catalyzes thethiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAsinto acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA moleculesinto acetoacetyl-CoA and could be involved in the production of ketonebodies. Also displays hydrolase activity on various fattyacyl-CoAs. Thereby, could be responsible for theproduction of acetate in a side reaction to beta-oxidation. Abolishes BNIP3-mediated apoptosis and mitochondrial damage. [1-2] Click to Show/Hide
Related KEGG Pathway
	Fatty acid degradation	hsa00071		Pathway Map
	Valine, leucine and isoleucine degradation	hsa00280		Pathway Map
	Metabolic pathways	hsa01100		Pathway Map
	Fatty acid metabolism	hsa01212		Pathway Map
	Fatty acid elongation	hsa00062		Pathway Map
3D Structure	PDB ID: 4C2J FASTA Download 2D PNG Download PDB File Download

Full List of Virus RNA Interacting with This Protien
*RNA Region: 3'-UTR (hCoV-19/IPBCAMS-YL01/2020 )*
RNA Region Details	RNA Info Click to show the detail information of this RNA binding region	[3]
Strains Name	hCoV-19/IPBCAMS-YL01/2020
Strains Family	Beta (B.1.351)
RNA Binding Region	3'-UTR
Virus Name	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Interaction Type	Unlikely to be direct binder
Infection Cells	Huh7.5.1 cells (Hepatocyte derived cellular carcinoma cell) (CVCL_E049 )
Cell Originated Tissue	Liver
Infection Time	30 h
Interaction Score	MIST = 0.685516119
Method Description	comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS)

Differential Gene Expression During SARS-COV-2 Infection

GEO Accession: GSE152641

Sample Type: Blood

Samples Details: Healthy Control: 24; COVID-19: 62

Platform: GPL24676 Illumina NovaSeq 6000

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GEO Accession: GSE162835

Sample Type: Nasopharyngeal Swabs

Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3

Platform: GPL24676 Illumina NovaSeq 6000

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GEO Accession: GSE175779

Sample Type: Human Bronchial Epithelial Cells

Samples Details: Healthy Control: 4 (0, 24, 48, 72 and 96 h); COVID-19: 4 (24, 48, 72 and 96 h)

Platform: GPL18573 Illumina NextSeq 500

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Protein Sequence Information
MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA Click to Show/Hide

References
1	The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3212-25.
2	Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines. Biochim Biophys Acta. 2008 Jun;1780(6):873-80.
3	Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2. Cell Res. 2022 Jan;32(1):9-23.