Details of Host Protein

 Host Protein General Information (ID: PT0146)
  Protein Name
Fatty acid desaturase 2 (FADS2)
  Gene Name
FADS2
  Host Species
Homo sapiens
  Uniprot Entry Name
FADS2_HUMAN
  Protein Families
Fatty acid desaturase type 1 family
  EC Number
1.14.19.3
  Subcellular Location
Multi-pass membrane protein
  External Link
NCBI Gene ID
9415
Uniprot ID
O95864
Ensembl ID
ENSG00000134824
HGNC ID
HGNC:3575
  Function in Host
Involved in the biosynthesis of highly unsaturated fattyacids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase thatintroduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is thedesaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively. Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) totetracosahexaenoate (24:6n-3), which is then converted todocosahexaenoate (DHA) (22:6n-3), an important lipid for nervous systemfunction. Desaturates hexadecanate (palmitate) toproduce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans andmajor component of human sebum, that has been implicated in thedevelopment of acne and may have potent antibacterial activity. It can also desaturate (11E) -octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6generating (6Z, 11E) -octadecadienoate. In addition toDelta-6 activity, this enzyme exhibits Delta-8 activity with slightbiases toward n-3 fatty acyl-CoA substrates. [1]
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  Related KEGG Pathway
PPAR signaling pathway hsa03320            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
Fatty acid metabolism hsa01212            Pathway Map 
alpha-Linolenic acid metabolism hsa00592            Pathway Map 
Biosynthesis of unsaturated fatty acids hsa01040            Pathway Map 
  3D Structure
AlphaFold ID: O95864 
  2D PNG Download  
  mmCIF File Download   
  PDB File Download   

 Full List of Virus RNA Interacting with This Protien
            RNA Region: 3'-UTR (hCoV-19/IPBCAMS-YL01/2020 )
              RNA Region Details RNA Info Click to show the detail information of this RNA binding region [2]
              Strains Name
hCoV-19/IPBCAMS-YL01/2020
              Strains Family
Beta (B.1.351)
              RNA Binding Region
3'-UTR
              Virus Name
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
              Interaction Type Unlikely to be direct binder
              Infection Cells Huh7.5.1 cells (Hepatocyte derived cellular carcinoma cell)  (CVCL_E049 )
              Cell Originated Tissue Liver
              Infection Time 30 h
              Interaction Score MIST = 0.846623144
              Method Description comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS)

Differential Gene Expression During SARS-COV-2 Infection
GEO Accession: GSE152641
Sample Type: Blood
Samples Details: Healthy Control: 24; COVID-19: 62
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE162835
Sample Type: Nasopharyngeal Swabs
Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE175779
Sample Type: Human Bronchial Epithelial Cells
Samples Details: Healthy Control: 4 (0, 24, 48, 72 and 96 h); COVID-19: 4 (24, 48, 72 and 96 h)
Platform: GPL18573 Illumina NextSeq 500
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Protein Phosphorylation after Virus Infection
Y63 [3]
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Protein Sequence Information
MGKGGNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSLKKSGKLWLDAYLHK
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References
1 Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. J Invest Dermatol. 2003 May;120(5):707-14.
2 Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2. Cell Res. 2022 Jan;32(1):9-23.
3 Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.