Details of Host Protein

 Host Protein General Information (ID: PT0552)
  Protein Name
Histone H4 (HNRNPCL1)
  Gene Name
H4C1
  Host Species
Homo sapiens
  Uniprot Entry Name
H4_HUMAN
  Protein Families
Histone H4 family
  Subcellular Location
Nucleus
  External Link
NCBI Gene ID
121504
Uniprot ID
P62805
Ensembl ID
ENSG00000282175
HGNC ID
HGNC:4783;HGNC:4785;HGNC:20510;HGNC:4793;HGNC:4790;HGNC:4787;HGNC:4788;HGNC:4784;HGNC:4781;HGNC:4789;HGNC:29607;HGNC:4794;HGNC:4791;HGNC:4782
  Function in Host
Core component of nucleosome. Nucleosomes wrap and compactDNA into chromatin, limiting DNA accessibility to the cellularmachineries which require DNA as a template. Histones thereby play acentral role in transcription regulation, DNA repair, DNA replicationand chromosomal stability. DNA accessibility is regulated via a complexset of post-translational modifications of histones, also calledhistone code, and nucleosome remodeling.
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  Related KEGG Pathway
Systemic lupus erythematosus hsa05322            Pathway Map 
Neutrophil extracellular trap formation hsa04613            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
Alcoholism hsa05034            Pathway Map 
  3D Structure
PDB ID: 1ZKK 
FASTA   Download
  2D PNG Download  
PDB File Download

 Full List of Virus RNA Interacting with This Protien
            RNA Region: 3'-UTR (hCoV-19/IPBCAMS-YL01/2020 )
              RNA Region Details RNA Info Click to show the detail information of this RNA binding region [1]
              Strains Name
hCoV-19/IPBCAMS-YL01/2020
              Strains Family
Beta (B.1.351)
              RNA Binding Region
3'-UTR
              Virus Name
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
              Interaction Type Unlikely to be direct binder
              Infection Cells Huh7.5.1 cells (Hepatocyte derived cellular carcinoma cell)  (CVCL_E049 )
              Cell Originated Tissue Liver
              Infection Time 30 h
              Interaction Score MIST = 0.668169604
              Method Description comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS)

Differential Gene Expression During SARS-COV-2 Infection
GEO Accession: GSE152641
Sample Type: Blood
Samples Details: Healthy Control: 24; COVID-19: 62
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE162835
Sample Type: Nasopharyngeal Swabs
Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3
Platform: GPL24676 Illumina NovaSeq 6000
  PNG Download  
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Protein Phosphorylation after Virus Infection
S48 [2]
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S48 [3]
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Protein Sequence Information
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
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References
1 Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2. Cell Res. 2022 Jan;32(1):9-23.
2 The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Aug 6;182(3):685-712.e19.
3 Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.