Lamins are components of the nuclear lamina, a fibrous layeron the nucleoplasmic side of the inner nuclear membrane, which isthought to provide a framework for the nuclear envelope and may alsointeract with chromatin. Lamin A and C are present in equal amounts inthe lamina of mammals. Recruited by DNA repair proteins XRCC4 and IFFO1to the DNA double-strand breaks (DSBs) to prevent chromosometranslocation by immobilizing broken DNA ends. Playsan important role in nuclear assembly, chromatin organization, nuclearmembrane and telomere dynamics. Required for normal development ofperipheral nervous system and skeletal muscle and for muscle satellitecell proliferation. Required for osteoblastogenesis andbone formation. Also prevents fat infiltration of muscle and bone marrow, helping tomaintain the volume and strength of skeletal muscle and bone. Required for cardiac homeostasis. [1-5]

METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM