Details of Host Protein

 Host Protein General Information (ID: PT0003)
  Protein Name
14-3-3 protein epsilon (14-3-3E)
  Gene Name
YWHAE
  Host Species
Homo sapiens
  Uniprot Entry Name
1433E_HUMAN
  Protein Families
14-3-3 family
  Subcellular Location
Nucleus Cytoplasm Melanosome
  External Link
NCBI Gene ID
7531
Uniprot ID
P62258
Ensembl ID
ENSG00000274894
HGNC ID
HGNC:12851
  Function in Host
Adapter protein implicated in the regulation of a largespectrum of both general and specialized signaling pathways. Binds to alarge number of partners, usually by recognition of a phosphoserine orphosphothreonine motif. Binding generally results in the modulation ofthe activity of the binding partner. Positivelyregulates phosphorylated protein HSF1 nuclear export to the cytoplasm. [1]
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  Related KEGG Pathway
NOD-like receptor signaling pathway hsa04621            Pathway Map 
Hepatitis C hsa05160            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
Cell cycle hsa04110            Pathway Map 
Oocyte meiosis hsa04114            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
Hippo signaling pathway hsa04390            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
  3D Structure
PDB ID: 2BR9 
FASTA   Download
  2D PNG Download  
PDB File Download

 Full List of Virus RNA Interacting with This Protien
            RNA Region: ORF10 (hCoV-19/Not Specified Virus Strain )
              RNA Region Details RNA Info Click to show the detail information of this RNA binding region [2]
              Strains Name
hCoV-19/Not Specified Virus Strain
              RNA Binding Region
ORF10
              Virus Name
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
              Infection Cells Calu-3 cells (Human Lung Cancer Cell)  (CVCL_0609 )
              Cell Originated Tissue Liver
              Interaction Score P-value < 0.05
              Method Description RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS)

Differential Gene Expression During SARS-COV-2 Infection
GEO Accession: GSE152641
Sample Type: Blood
Samples Details: Healthy Control: 24; COVID-19: 62
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE162835
Sample Type: Nasopharyngeal Swabs
Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3
Platform: GPL24676 Illumina NovaSeq 6000
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Protein Sequence Information
MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ
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References
1 Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol. 2003 Sep;23(17):6013-26.
2 Mapping the host protein interactome of non-coding regions in SARS-CoV-2 genome. bioRxiv. 2021 Jun; DOI:10.1101/2021.06.19.449092.