Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasisby removing misfolded or damaged proteins, which could impair cellularfunctions, and by removing proteins whose functions are no longerrequired. Therefore, the proteasome participates in numerous cellularprocesses, including cell cycle progression, apoptosis, or DNA damagerepair. PSMC2 belongs to the heterohexameric ring of AAA (ATPasesassociated with diverse cellular activities) proteins that unfoldsubiquitinated target proteins that are concurrently translocated into aproteolytic chamber and degraded into peptides.

MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN