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ManualDetails of Host Protein
| Host Protein General Information (ID: PT0063) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Protein Name |
3-mercaptopyruvate sulfurtransferase (MST)
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Gene Name |
MPST
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| Host Species |
Homo sapiens
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Uniprot Entry Name |
THTM_HUMAN
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| EC Number |
2.8.1.2
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| Subcellular Location |
Cytoplasm Mitochondrion Cell junction; synapse; synaptosome
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| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
Transfer of a sulfur ion to cyanide or to other thiolcompounds. Also has weak rhodanese activity. Detoxifies cyanide and isrequired for thiosulfate biosynthesis. Acts as an antioxidant. Incombination with cysteine aminotransferase (CAT), contributes to thecatabolism of cysteine and is an important producer of hydrogen sulfidein the brain, retina and vascular endothelial cells. Hydrogen sulfideH (2) S is an important synaptic modulator, signaling molecule, smoothmuscle contractor and neuroprotectant. Its production by the 3MST/CATpathway is regulated by calcium ions.
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| Related KEGG Pathway | |||||||||
| Sulfur relay system | hsa04122 |
Pathway Map 
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| Cysteine and methionine metabolism | hsa00270 |
Pathway Map 
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| Sulfur metabolism | hsa00920 |
Pathway Map 
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| Metabolic pathways | hsa01100 |
Pathway Map 
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| 3D Structure |
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| Full List of Virus RNA Interacting with This Protien | |||||||||
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| RNA Region: Not Specified Virus Region (hCoV-19/Not Specified Virus Strain ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[1] | |||||||
| Strains Name |
hCoV-19/Not Specified Virus Strain
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| RNA Binding Region |
Not Specified Virus Region
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Huh7 cells (liver carcinoma cell) (CVCL_0336 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Infection Time | 24h | ||||||||
| Interaction Score | log2FC = 3.86924E+14 | ||||||||
| Method Description | RNA antisense purification and quantitative mass spectrometry (RAP-MS); Tandem mass tag (TMT) labelling; liquid chromatography tandem mass spectrometry (LC-MS/MS); Westernblot | ||||||||
