Details of Host Protein

KEGG: hsa05171 Pathway Download ×

KEGG: hsa03010 Pathway Download ×

Host Protein General Information (ID: PT0110)
Protein Name		60S ribosomal protein L27 (RPL26)			Gene Name		RPL26
Host Species		Homo sapiens			Uniprot Entry Name		RL26_HUMAN
Protein Families		Universal ribosomal protein uL24 family
External Link
		NCBI Gene ID			6154
		Uniprot ID			P61254
		Ensembl ID			ENSG00000161970
		HGNC ID			HGNC:10327
Function in Host		Component of the large ribosomal subunit.     Click to Show/Hide
Related KEGG Pathway
		Coronavirus disease - COVID-19			hsa05171			Pathway Map
		Ribosome			hsa03010			Pathway Map
3D Structure		PDB ID: 4UG0  FASTA   Download   2D PNG Download   PDB File Download

Function of This Protein During Virus Infection
Virus Name		SARS-COV-2			Protein Function		Anti-viral		[1]
Infected Tissue		Lung			Infection Time		7-9 Days
Infected Cell		Calu-3 Cells (Human epithelial cell line)			Cellosaurus ID		CVCL_0609
Method Description		To detect the role of host protein RPL26 in viral infection, RPL26 protein knockout Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen.
Results		It is reported that knockout of RPL26 increases SARS-CoV-2 RNA levels compared with control group.

Host Protein - Virus RNA Network
Network Download

Full List of Virus RNA Interacting with This Protien
RNA Region: 5'-UTR (hCoV-19/South Korea/KCDC03/2020 )
RNA Region Details			RNA Info Click to show the detail information of this RNA binding region						[2]
Strains Name			hCoV-19/South Korea/KCDC03/2020
Strains Family			Alpha (B.1.1.7)
RNA Binding Region			5'-UTR
Virus Name			Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Interaction Type			Directly bind to SARS-CoV-23 RNA's 5' UTR region
Infection Cells			Vero cells (epithelial kidney cell)  (CVCL_0059 )
Cell Originated Tissue			kidney
Infection Time			24 h
Interaction Score			P-adjust < 0.05
Method Description			Modified RNA antisense purification coupled with mass spectrometry (RAP-MS); label-free quantification (LFQ); liquid chromatography with tandem mass spectrometry (LC-MS/MS)
RNA Region: Not Specified Virus Region (hCov-OC43/VR-759 Quebec/2019 )
RNA Region Details			RNA Info Click to show the detail information of this RNA binding region						[2]
Strains Name			hCov-OC43/VR-759 Quebec/2019
Strains Family			Beta
RNA Binding Region			Not Specified Virus Region
Virus Name			Human coronavirus OC43 (HCov-OC43)
Infection Cells			HCT-8 cells (Human ileocaecal adenocarcinoma cell) HCT-8 cells (Human ileocaecal adenocarcinoma cell)  (CVCL_2478 )
Cell Originated Tissue			Ileocecum
Infection Time			12h; 24; 36h; 48h
Interaction Score			p_value < 0.05; FDR < 10%
Method Description			Modified RNA antisense purification coupled with mass spectrometry (RAP-MS); label-free quantification (LFQ); liquid chromatography with tandem mass spectrometry (LC-MS/MS)

Differential Gene Expression During SARS-COV-2 Infection

GEO Accession: GSE152641 Sample Type: Blood Samples Details: Healthy Control: 24; COVID-19: 62 Platform: GPL24676 Illumina NovaSeq 6000   PNG Download   GEO Accession: GSE162835 Sample Type: Nasopharyngeal Swabs Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3 Platform: GPL24676 Illumina NovaSeq 6000   PNG Download   GEO Accession: GSE175779 Sample Type: Human Bronchial Epithelial Cells Samples Details: Healthy Control: 4 (0, 24, 48, 72 and 96 h); COVID-19: 4 (24, 48, 72 and 96 h) Platform: GPL18573 Illumina NextSeq 500   PNG Download

Protein Phosphorylation after Virus Infection
S35 [3]   PNG Download

Protein Sequence Information
MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEETIEKMQE     Click to Show/Hide

References
1	Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2. Nat Commun. 2022 Apr 25;13(1):2237.
2	The SARS-CoV-2 RNA interactome. Mol Cell. 2021 Jul 1;81(13):2838-2850.e6.
3	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.