Details of Host Protein

 Host Protein General Information (ID: PT0143)
  Protein Name
Actin-related protein 2 (ARP2)
  Gene Name
ACTR2
  Host Species
Homo sapiens
  Uniprot Entry Name
ARP2_HUMAN
  Protein Families
Actin family
  Subcellular Location
Cytoplasm; cytoskeleton Cell projection Nucleus
  External Link
NCBI Gene ID
10097
Uniprot ID
P61160
Ensembl ID
ENSG00000151475
HGNC ID
HGNC:169
  Function in Host
ATP-binding component of the Arp2/3 complex, a multiproteincomplex that mediates actin polymerization upon stimulation bynucleation-promoting factor (NPF). The Arp2/3 complexmediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems tocontact the pointed end of the daughter actin filament. In podocytes, required for the formation oflamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3complex also promotes actin polymerization in the nucleus, therebyregulating gene transcription and repair of damaged DNA. The Arp2/3 complex promoteshomologous recombination (HR) repair in response to DNA damage bypromoting nuclear actin polymerization, leading to drive motility ofdouble-strand breaks (DSBs). [1-2]
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  Related KEGG Pathway
Fc gamma R-mediated phagocytosis hsa04666            Pathway Map 
Bacterial invasion of epithelial cells hsa05100            Pathway Map 
Pathogenic Escherichia coli infection hsa05130            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Endocytosis hsa04144            Pathway Map 
Tight junction hsa04530            Pathway Map 
  3D Structure
PDB ID: 6UHC 
FASTA   Download
  2D PNG Download  
PDB File Download

 Full List of Virus RNA Interacting with This Protien
            RNA Region: Not Specified Virus Region (hCoV-19/Not Specified Virus Strain )
              RNA Region Details RNA Info Click to show the detail information of this RNA binding region [3]
              Strains Name
hCoV-19/Not Specified Virus Strain
              RNA Binding Region
Not Specified Virus Region
              Virus Name
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
              Infection Cells Huh7 cells (liver carcinoma cell)  (CVCL_0336 )
              Cell Originated Tissue Liver
              Infection Time 24h
              Interaction Score log2FC = 8.76745E+13
              Method Description RNA antisense purification and quantitative mass spectrometry (RAP-MS); Tandem mass tag (TMT) labelling; liquid chromatography tandem mass spectrometry (LC-MS/MS); Westernblot

Differential Gene Expression During SARS-COV-2 Infection
GEO Accession: GSE152641
Sample Type: Blood
Samples Details: Healthy Control: 24; COVID-19: 62
Platform: GPL24676 Illumina NovaSeq 6000
  PNG Download  
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GEO Accession: GSE162835
Sample Type: Nasopharyngeal Swabs
Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3
Platform: GPL24676 Illumina NovaSeq 6000
  PNG Download  
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Protein Sequence Information
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
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References
1 Advillin acts upstream of phospholipase C in steroid-resistant nephrotic syndrome. J Clin Invest. 2017 Dec 1;127(12):4257-4269.
2 Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. Nature. 1997 Jan 16;385(6613):265-9.
3 The SARS-CoV-2 RNA-protein interactome in infected human cells. Nat Microbiol. 2021 Mar;6(3):339-353.