Details of Host Protein
Host Protein General Information (ID: PT0155) | |||||||||
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Protein Name |
Adenylosuccinate lyase (ADSL)
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Gene Name |
ADSL
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Host Species |
Homo sapiens
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Uniprot Entry Name |
PUR8_HUMAN
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Protein Families |
Lyase 1 family
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EC Number |
4.3.2.2
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External Link | |||||||||
NCBI Gene ID | |||||||||
Uniprot ID | |||||||||
Ensembl ID | |||||||||
HGNC ID | |||||||||
Function in Host |
Catalyzes two non-sequential steps in de novo AMP synthesis:converts (S) -2- (5-amino-1- (5-phospho-D-ribosyl) imidazole-4-carboxamido) succinate (SAICAR) to fumarate plus 5-amino-1- (5-phospho-D-ribosyl) imidazole-4-carboxamide, and thereby also contributes to denovo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
[1]
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Related KEGG Pathway | |||||||||
Alanine, aspartate and glutamate metabolism | hsa00250 |
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Metabolic pathways | hsa01100 |
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Nucleotide metabolism | hsa01232 |
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Biosynthesis of cofactors | hsa01240 |
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Purine metabolism | hsa00230 |
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3D Structure |
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Function of This Protein During Virus Infection | |||||||||
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Virus Name | SARS-COV-2 | Protein Function | Anti-viral | [2] | |||||
Infected Tissue | Lung | Infection Time | 7-9 Days | ||||||
Infected Cell | Calu-3 Cells (Human epithelial cell line) | Cellosaurus ID | CVCL_0609 | ||||||
Method Description | To detect the role of host protein ADSL in viral infection, ADSL protein knockout Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen. | ||||||||
Results | It is reported that knockout of ADSL increases SARS-CoV-2 RNA levels compared with control group. |
Full List of Virus RNA Interacting with This Protien | |||||||||
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RNA Region: Not Specified Virus Region (hCoV-19/USA/WA1/2020 ) | |||||||||
RNA Region Details |
RNA Info
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[3] | |||||||
Strains Name |
hCoV-19/USA/WA1/2020
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Strains Family |
Alpha (B.1.1.7)
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RNA Binding Region |
Not Specified Virus Region
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Infection Cells | Huh7.5 cells (Hepatocyte derived cellular carcinoma cell) (CVCL_7927 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Infection Time | 48 h | ||||||||
Interaction Score | FDR ≤ 0.05 | ||||||||
Method Description | comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS) |
Differential Gene Expression During SARS-COV-2 Infection | |||||||||||||||||||||||||||||||||||||||||
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Protein Phosphorylation after Virus Infection | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S9
[4] |
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Protein Sequence Information | ||||||||||||||
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MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKAELCL
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