Anchoring protein that mediates the subcellularcompartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex ontomitotic chromosomes, which is required for maintenance of chromosomesin a condensed form throughout mitosis. Recruits condensin complexsubunit NCAPD2 to chromosomes required for chromatin condensation; thefunction appears to be independent from PKA-anchoring. May help to deliver cyclin D/E toCDK4 to facilitate cell cycle progression. Requiredfor cell cycle G2/M transition and histone deacetylation duringmitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatinleading to deacetylation and subsequent phosphorylation at 'Ser-10' ofhistone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERKactivation thus inducing cell proliferation. May beinvolved in regulation of DNA replication by acting as scaffold forMCM2. Enhances HMT activity of the KMT2 familyMLL4/WBP7 complex and is involved in transcriptional regulation. In ateratocarcinoma cell line is involved in retinoic acid-mediatedinduction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 tothe nucleus in apoptotic cells. May act as a carrierprotein of GJA1 for its transport to the nucleus. Mayplay a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates withribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter andtranscribed regions. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression ofTNF-alpha in early stages of LPS-induced macrophage activation; thefunction probably implicates targeting of PKA to NFKB1. [1-6]

MDQGYGGYGAWSAGPANTQGAYGTGVASWQGYENYNYYGAQNTSVTTGATYSYGPASWEAAKANDGGLAAGAPAMHMASYGPEPCTDNSDSLIAKINQRLDMMSKEGGRGGSGGGGEGIQDRESSFRFQPFESYDSRPCLPEHNPYRPSYSYDYEFDLGSDRNGSFGGQYSECRDPARERGSLDGFMRGRGQGRFQDRSNPGTFMRSDPFVPPAASSEPLSTPWNELNYVGGRGLGGPSPSRPPPSLFSQSMAPDYGVMGMQGAGGYDSTMPYGCGRSQPRMRDRDRPKRRGFDRFGPDGTGRKRKQFQLYEEPDTKLARVDSEGDFSENDDAAGDFRSGDEEFKGEDELCDSGRQRGEKEDEDEDVKKRREKQRRRDRTRDRAADRIQFACSVCKFRSFDDEEIQKHLQSKFHKETLRFISTKLPDKTVEFLQEYIVNRNKKIEKRRQELMEKETAKPKPDPFKGIGQEHFFKKIEAAHCLACDMLIPAQPQLLQRHLHSVDHNHNRRLAAEQFKKTSLHVAKSVLNNRHIVKMLEKYLKGEDPFTSETVDPEMEGDDNLGGEDKKETPEEVAADVLAEVITAAVRAVDGEGAPAPESSGEPAEDEGPTDTAEAGSDPQAEQLLEEQVPCGTAHEKGVPKARSEAAEAGNGAETMAAEAESAQTRVAPAPAAADAEVEQTDAESKDAVPTE