Details of Host Protein

 Host Protein General Information (ID: PT0184)
  Protein Name
Annexin A5 (ANXA5)
  Gene Name
ANXA5
  Host Species
Homo sapiens
  Uniprot Entry Name
ANXA5_HUMAN
  Protein Families
Annexin family
  External Link
NCBI Gene ID
308
Uniprot ID
P08758
Ensembl ID
ENSG00000164111
HGNC ID
HGNC:543
  Function in Host
This protein is an anticoagulant protein that acts as anindirect inhibitor of the thromboplastin-specific complex, which isinvolved in the blood coagulation cascade.
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  3D Structure
PDB ID: 1ANW 
FASTA   Download
  2D PNG Download  
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 Full List of Virus RNA Interacting with This Protien
            RNA Region: Not Specified Virus Region (hCoV-19/USA/WA1/2020 )
              RNA Region Details RNA Info Click to show the detail information of this RNA binding region [1]
              Strains Name
hCoV-19/USA/WA1/2020
              Strains Family
Alpha (B.1.1.7)
              RNA Binding Region
Not Specified Virus Region
              Virus Name
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
              Infection Cells Huh7.5 cells (Hepatocyte derived cellular carcinoma cell)  (CVCL_7927 )
              Cell Originated Tissue Liver
              Infection Time 48 h
              Interaction Score FDR ≤ 0.05
              Method Description comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS)

Differential Gene Expression During SARS-COV-2 Infection
GEO Accession: GSE152641
Sample Type: Blood
Samples Details: Healthy Control: 24; COVID-19: 62
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE162835
Sample Type: Nasopharyngeal Swabs
Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE175779
Sample Type: Human Bronchial Epithelial Cells
Samples Details: Healthy Control: 4 (0, 24, 48, 72 and 96 h); COVID-19: 4 (24, 48, 72 and 96 h)
Platform: GPL18573 Illumina NextSeq 500
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Potential Drug(s) that Targets This Protein
Drug Name DrunkBank ID Pubchem ID TTD ID REF
AC1NRBS8 DB03935  . D0KL1I  [2]
Copper DB09130  23978  D01WMJ  [2]
Glycerophosphorylserine DB02497  444182  . [2]
K201 free base DB02929  1715  . [2]
L-thioproline DB02846  93176  . [2]
O35QN01X8F DB03484  444183  . [2]
SGN DB03959  444389  D0B0SV  [2]
Synalar DB00591  6215  D02QJH  [2]
UAP DB03981  444552  D0X4AL  [2]

Protein Sequence Information
MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD
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References
1 Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Cell. 2021 Apr 29;184(9):2394-2411.e16.
2 Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis. EMBO J. 2021 Sep 1;40(17):e107776.