Mitochondrial membrane ATP synthase (F (1) F (0) ATP synthase orComplex V) produces ATP from ADP in the presence of a proton gradientacross the membrane which is generated by electron transport complexesof the respiratory chain. F-type ATPases consist of two structuraldomains, F (1) - containing the extramembraneous catalytic core, andF (0) - containing the membrane proton channel, linked together by acentral stalk and a peripheral stalk. During catalysis, ATP synthesisin the catalytic domain of F (1) is coupled via a rotary mechanism ofthe central stalk subunits to proton translocation. Part of the complexF (1) domain and the central stalk which is part of the complex rotaryelement. The gamma subunit protrudes into the catalytic domain formedof alpha (3) beta (3). Rotation of the central stalk against thesurrounding alpha (3) beta (3) subunits leads to hydrolysis of ATP inthree separate catalytic sites on the beta subunits.

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