Details of Host Protein

 Host Protein General Information (ID: PT0283)
  Protein Name
Coiled-coil domain-containing protein 25 (COL6A5)
  Gene Name
CCDC25
  Host Species
Homo sapiens
  Uniprot Entry Name
CCD25_HUMAN
  Protein Families
CCDC25 family
  Subcellular Location
Plasma membrane
  External Link
NCBI Gene ID
55246
Uniprot ID
Q86WR0
Ensembl ID
ENSG00000172752
HGNC ID
HGNC:25591
  Function in Host
Transmembrane receptor that senses neutrophil extracellulartraps (NETs) and triggers the ILK-PARVB pathway to enhance cellmotility. NETs are mainly composed of DNA fibers andare released by neutrophils to bind pathogens during inflammation. Formation of NETs is also associated with cancermetastasis, NET-DNA acting as a chemotactic factor to attract cancercells. Specifically binds NETs on its extracellularregion, in particular the 8-OHdG-enriched DNA present in NETs, andrecruits ILK, initiating the ILK-PARVB cascade to induce cytoskeletonrearrangement and directional migration of cells. Inthe context of cancer, promotes cancer metastasis by sensing NETs andpromoting migration of tumor cells.
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  3D Structure
AlphaFold ID: Q86WR0 
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  mmCIF File Download   
  PDB File Download   

 Full List of Virus RNA Interacting with This Protien
            RNA Region: 3'-UTR (hCoV-19/Wuhan-Hu-1/2019 )
              RNA Region Details RNA Info Click to show the detail information of this RNA binding region [1]
              Strains Name
hCoV-19/Wuhan-Hu-1/2019
              Strains Family
Beta (B.1.351)
              RNA Binding Region
3'-UTR
              Virus Name
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
              Infection Cells HEK293 Cells (Human embryonic kidney cell)  (CVCL_0045 )
              Cell Originated Tissue Liver
              Infection Time 48 h
              Interaction Score Prot score = 16
              Method Description RNA-protein interaction detection (RaPID) assay; liquid chromatography with tandem mass spectrometry (LC-MS/MS)

Differential Gene Expression During SARS-COV-2 Infection
GEO Accession: GSE152641
Sample Type: Blood
Samples Details: Healthy Control: 24; COVID-19: 62
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE162835
Sample Type: Nasopharyngeal Swabs
Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3
Platform: GPL24676 Illumina NovaSeq 6000
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Protein Sequence Information
MVFYFTSSSVNSSAYTIYMGKDKYENEDLIKHGWPEDIWFHVDKLSSAHVYLRLHKGENIEDIPKEVLMDCAHLVKANSIQGCKMNNVNVVYTPWSNLKKTADMDVGQIGFHRQKDVKIVTVEKKVNEILNRLEKTKVERFPDLAAEKECRDREERNEKKAQIQEMKKREKEEMKKKREMDELRSYSSLMKVENMSSNQDGNDSDEFM
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References
1 RNA-Protein Interaction Analysis of SARS-CoV-2 5 and 3 Untranslated Regions Reveals a Role of Lysosome-Associated Membrane Protein-2a during Viral Infection. mSystems. 2021 Aug 31;6(4):e0064321.