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ManualDetails of Host Protein
| Host Protein General Information (ID: PT0295) | |||||||||
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| Protein Name |
COP9 signalosome complex subunit 4 (COPS4)
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Gene Name |
COPS4
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| Host Species |
Homo sapiens
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Uniprot Entry Name |
CSN4_HUMAN
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| Protein Families |
CSN4 family
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| Subcellular Location |
Cytoplasm Nucleus Cytoplasmic vesicle; secretory vesicle
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| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
Component of the COP9 signalosome complex (CSN), a complexinvolved in various cellular and developmental processes. The CSNcomplex is an essential regulator of the ubiquitin (Ubl) conjugationpathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activityof SCF-type complexes such as SCF, CSA or DDB2. Also involved in thedeneddylation of non-cullin subunits such as STON2. The complex is alsoinvolved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via itsassociation with CK2 and PKD kinases. CSN-dependent phosphorylation ofTP53 and JUN promotes and protects degradation by the Ubl system, respectively.
[1-6]
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| 3D Structure |
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| Function of This Protein During Virus Infection | |||||||||
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| Virus Name | SARS-COV-2 | Protein Function | Anti-viral | [7] | |||||
| Infected Tissue | Lung | Infection Time | 7-9 Days | ||||||
| Infected Cell | Calu-3 Cells (Human epithelial cell line) | Cellosaurus ID | CVCL_0609 | ||||||
| Method Description | To detect the role of host protein COPS4 in viral infection, COPS4 protein knockout Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen. | ||||||||
| Results | It is reported that knockout of COPS4 increases SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Full List of Virus RNA Interacting with This Protien | |||||||||
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| RNA Region: ORF10 (hCoV-19/Not Specified Virus Strain ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[8] | |||||||
| Strains Name |
hCoV-19/Not Specified Virus Strain
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| RNA Binding Region |
ORF10
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Calu-3 cells (Human Lung Cancer Cell) (CVCL_0609 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Interaction Score | P-value < 0.05 | ||||||||
| Method Description | RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) | ||||||||
