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ManualDetails of Host Protein
| Host Protein General Information (ID: PT0308) | |||||||||
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| Protein Name |
Cullin-associated NEDD8-dissociated protein 1 (CAND1)
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Gene Name |
CAND1
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| Host Species |
Homo sapiens
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Uniprot Entry Name |
CAND1_HUMAN
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| Protein Families |
CAND family
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| Subcellular Location |
Cytoplasm Nucleus
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| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key rolein the cellular repertoire of SCF complexes. Acts as a F-box proteinexchange factor. The exchange activity of CAND1 is coupled with cyclesof neddylation conjugation: in the deneddylated state, cullin-bindingCAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex andpromoting exchange of the F-box protein. Probably plays a similar rolein other cullin-RING E3 ubiquitin ligase complexes.
[1-6]
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| 3D Structure |
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| Function of This Protein During Virus Infection | |||||||||
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| Virus Name | SARS-COV-2 | Protein Function | Anti-viral | [7] | |||||
| Infected Tissue | Lung | Infection Time | 7-9 Days | ||||||
| Infected Cell | Calu-3 Cells (Human epithelial cell line) | Cellosaurus ID | CVCL_0609 | ||||||
| Method Description | To detect the role of host protein CAND1 in viral infection, CAND1 protein knockout Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen. | ||||||||
| Results | It is reported that knockout of CAND1 increases SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Full List of Virus RNA Interacting with This Protien | |||||||||
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| RNA Region: Not Specified Virus Region (hCoV-19/USA/WA1/2020 ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[8] | |||||||
| Strains Name |
hCoV-19/USA/WA1/2020
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| Strains Family |
Alpha (B.1.1.7)
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| RNA Binding Region |
Not Specified Virus Region
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Huh7.5 cells (Hepatocyte derived cellular carcinoma cell) (CVCL_7927 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Infection Time | 48 h | ||||||||
| Interaction Score | FDR ≤ 0.05 | ||||||||
| Method Description | comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS) | ||||||||
