Details of Host Protein
Host Protein General Information (ID: PT0337) | |||||||||
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Protein Name |
Dimethyladenosine transferase 2 (TFB2M)
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Gene Name |
TFB2M
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Host Species |
Homo sapiens
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Uniprot Entry Name |
TFB2M_HUMAN
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Protein Families |
Class I-like SAM-binding methyltransferase superfamily
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EC Number |
2.1.1.-
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Subcellular Location |
Mitochondrion
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External Link | |||||||||
NCBI Gene ID | |||||||||
Uniprot ID | |||||||||
Ensembl ID | |||||||||
HGNC ID | |||||||||
Function in Host |
S-adenosyl-L-methionine-dependent rRNA methyltransferasewhich may methylate two specific adjacent adenosines in the loop of aconserved hairpin near the 3'-end of 12S mitochondrial rRNA. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basaltranscription of mitochondrial DNA. In this complex, TFAM recruitsPOLRMT to a specific promoter whereas TFB2M induces structural changesin POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulatestranscription independently of the methyltransferase activity.
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3D Structure |
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Full List of Virus RNA Interacting with This Protien | |||||||||
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RNA Region: Not Specified Virus Region (hCoV-19/England/02/2020 ) | |||||||||
RNA Region Details |
RNA Info
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[7] | |||||||
Strains Name |
hCoV-19/England/02/2020
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
Not Specified Virus Region
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Infection Cells | Calu-3 cells (Human lung cancer cell) (CVCL_0609 ) | ||||||||
Cell Originated Tissue | Lung | ||||||||
Infection Time | 24 h | ||||||||
Interaction Score | P-adjust = 0.096 | ||||||||
Method Description | UV protein-RNA crosslinking; RNA interactome capture (cRIC); RNA antisense purification coupled with mass spectrometry (RAP-MS) |
Differential Gene Expression During SARS-COV-2 Infection | |||||||||||||||||||||||||||||||||||||||||
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Protein Sequence Information | ||||||||||||||
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MWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLAQIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR
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