Details of Host Protein

 Host Protein General Information (ID: PT0358)
  Protein Name
DnaJ homolog subfamily B member 11 (DNAJB11)
  Gene Name
DNAJB11
  Host Species
Homo sapiens
  Uniprot Entry Name
DJB11_HUMAN
  Subcellular Location
Endoplasmic reticulum lumen
  External Link
NCBI Gene ID
51726
Uniprot ID
Q9UBS4
Ensembl ID
ENSG00000090520
HGNC ID
HGNC:14889
  Function in Host
As a co-chaperone for HSPA5 it is required for properfolding, trafficking or degradation of proteins. Binds directly to both unfoldedproteins that are substrates for ERAD and nascent unfolded peptidechains, but dissociates from the HSPA5-unfolded protein complex beforefolding is completed. May help recruiting HSPA5 andother chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correcttrafficking of PKD1. [1-3]
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  Related KEGG Pathway
Protein processing in endoplasmic reticulum hsa04141            Pathway Map 
  3D Structure
AlphaFold ID: Q9UBS4 
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  mmCIF File Download   
  PDB File Download   

 Full List of Virus RNA Interacting with This Protien
            RNA Region: ORF10 (hCoV-19/Not Specified Virus Strain )
              RNA Region Details RNA Info Click to show the detail information of this RNA binding region [4]
              Strains Name
hCoV-19/Not Specified Virus Strain
              RNA Binding Region
ORF10
              Virus Name
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
              Infection Cells Calu-3 cells (Human Lung Cancer Cell)  (CVCL_0609 )
              Cell Originated Tissue Liver
              Interaction Score P-value < 0.05
              Method Description RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS)

Differential Gene Expression During SARS-COV-2 Infection
GEO Accession: GSE152641
Sample Type: Blood
Samples Details: Healthy Control: 24; COVID-19: 62
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE162835
Sample Type: Nasopharyngeal Swabs
Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE175779
Sample Type: Human Bronchial Epithelial Cells
Samples Details: Healthy Control: 4 (0, 24, 48, 72 and 96 h); COVID-19: 4 (24, 48, 72 and 96 h)
Platform: GPL18573 Illumina NextSeq 500
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Protein Sequence Information
MAPQNLSTFCLLLLYLIGAVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPQAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHPIFERRGDDLYTNVTISLVESLVGFEMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEEAREGIKQLLKQGSVQKVYNGLQGY
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References
1 ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP s interactions with unfolded substrates. Mol Biol Cell. 2005 Jan;16(1):40-50.
2 Monoallelic Mutations to DNAJB11 Cause Atypical Autosomal-Dominant Polycystic Kidney Disease. Am J Hum Genet. 2018 May 3;102(5):832-844.
3 HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum of human cells. J Biol Chem. 2000 Aug 11;275(32):24984-92.
4 Mapping the host protein interactome of non-coding regions in SARS-CoV-2 genome. bioRxiv. 2021 Jun; DOI:10.1101/2021.06.19.449092.