Details of Host Protein

 Host Protein General Information (ID: PT0418)
  Protein Name
EIF4E messenger RNA (EIF4E)
  Gene Name
EIF4E
  Host Species
Homo sapiens
  Uniprot Entry Name
IF4E_HUMAN
  Protein Families
Eukaryotic initiation factor 4E family
  Subcellular Location
Cytoplasm; Stress granule Nucleus
  External Link
NCBI Gene ID
1977
Uniprot ID
P06730
Ensembl ID
ENSG00000151247
HGNC ID
HGNC:3287
  Function in Host
Recognizes and binds the 7-methylguanosine-containing mRNAcap during an early step in the initiation of protein synthesis andfacilitates ribosome binding by inducing the unwinding of the mRNAssecondary structures. In addition toits role in translation initiation, also acts as a regulator oftranslation and stability in the cytoplasm. Componentof the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap andmediates translational repression: in the complex, EIF4E mediates thebinding to the mRNA cap. Component of a multiproteincomplex that sequesters and represses translation of proneurogenicfactors during neurogenesis. In P-bodies, component ofa complex that mediates the storage of translationally inactive mRNAsin the cytoplasm and prevents their degradation. Mayplay an important role in spermatogenesis through translationalregulation of stage-specific mRNAs during germ cell development. [1]
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  Related KEGG Pathway
HIF-1 signaling pathway hsa04066            Pathway Map 
mTOR signaling pathway hsa04150            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
Longevity regulating pathway hsa04211            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
Insulin signaling pathway hsa04910            Pathway Map 
  3D Structure
PDB ID: 1IPB 
FASTA   Download
  2D PNG Download  
PDB File Download

 Full List of Virus RNA Interacting with This Protien
            RNA Region: Not Specified Virus Region (hCoV-19/England/02/2020 )
              RNA Region Details RNA Info Click to show the detail information of this RNA binding region [2]
              Strains Name
hCoV-19/England/02/2020
              Strains Family
Beta (B.1.351)
              RNA Binding Region
Not Specified Virus Region
              Virus Name
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
              Infection Cells Calu-3 cells (Human lung cancer cell)  (CVCL_0609 )
              Cell Originated Tissue Lung
              Infection Time 24 h
              Interaction Score P-adjust = 0.022
              Method Description UV protein-RNA crosslinking; RNA interactome capture (cRIC); RNA antisense purification coupled with mass spectrometry (RAP-MS)

Differential Gene Expression During SARS-COV-2 Infection
GEO Accession: GSE152641
Sample Type: Blood
Samples Details: Healthy Control: 24; COVID-19: 62
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE162835
Sample Type: Nasopharyngeal Swabs
Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3
Platform: GPL24676 Illumina NovaSeq 6000
  PNG Download  
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GEO Accession: GSE175779
Sample Type: Human Bronchial Epithelial Cells
Samples Details: Healthy Control: 4 (0, 24, 48, 72 and 96 h); COVID-19: 4 (24, 48, 72 and 96 h)
Platform: GPL18573 Illumina NextSeq 500
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Protein Phosphorylation after Virus Infection
S209 [3]
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S24 [4]
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Potential Drug(s) that Targets This Protein
Drug Name DrunkBank ID Pubchem ID TTD ID REF
Lopinavir DB01601  92727  D0U5GB  [5]
Ritonavir DB00503  392622  D0ZU9R  [5]
SIROLIMUS DB00877  5284616  D03LJR  [6]
Triparanol . 5717952  . [3]
Triparanol . . . [5]
Vitamin C DB14482  54670067  D07AHW  [5]
Vitamin E DB00163  14985  D02TQO  [5]

Protein Sequence Information
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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References
1 Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing. Nucleic Acids Res. 2014 Mar;42(5):3298-313.
2 Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection. Mol Cell. 2021 Jul 1;81(13):2851-2867.e7.
3 The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Aug 6;182(3):685-712.e19.
4 Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.
5 Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs. Virology. 2021 Mar;555:10-18.
6 Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Cell. 2021 Apr 29;184(9):2394-2411.e16.