Histone acetyltransferase that plays a role in differentbiological processes including cell cycle progression, glucosemetabolism, histone production or DNA damage repair. Coordinates histoneproduction and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to supportchromatin replication and acetylation. Since transcription of H4 genesis tightly coupled to S-phase, plays an important role in S-phase entryand progression. Promotes homologous recombination inDNA repair by facilitating histone turnover and incorporation ofacetylated H3. 3 at sites of double-strand breaks. Inaddition, acetylates other substrates such as chromatin-relatedproteins. Acetylates also RSAD2 which mediates theinteraction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2ubiquitination and subsequent degradation. [1-3]

MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMVIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMRKCLRPEELTNQMNQIEISMQHEQLEESFQELVEDYRRVIERLAQE