Plays an important role in chaperone-mediated autophagy, aprocess that mediates lysosomal degradation of proteins in response tovarious stresses and as part of the normal turnover of proteins with along biological half-live. Functions bybinding target proteins, such as GAPDH and MLLT11, and targeting themfor lysosomal degradation. Plays a role in lysosomal proteindegradation in response to starvation. Required for thefusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels ofVAMP8, but fail to accumulate STX17 on autophagosomes, which is themost likely explanation for the lack of fusion between autophagosomesand lysosomes. Required for normal degradation of thecontents of autophagosomes. Required for efficientMHCII-mediated presentation of exogenous antigens via its function inlysosomal protein degradation; antigenic peptides generated byproteases in the endosomal/lysosomal compartment are captured bynascent MHCII subunits. Is not required for efficientMHCII-mediated presentation of endogenous antigens. [1-5]

MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYAKWQMNFTVRYETTNKTYKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANFTKAASTYSIDSVSFSYNTGDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLEKNDVVQHYWDVLVQAFVQNGTVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKPEAGTYSVNNGNDTCLLATMGLQLNITQDKVASVININPNTTHSTGSCRSHTALLRLNSSTIKYLDFVFAVKNENRFYLKEVNISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKEQTVSVSGAFQINTFDLRVQPFNVTQGKYSTAQDCSADDDNFLVPIAVGAALAGVLILVLLAYFIGLKHHHAGYEQF