Zinc-finger RNA-binding protein that destabilizes severalcytoplasmic AU-rich element (ARE) -containing mRNA transcripts bypromoting their poly (A) tail removal or deadenylation, and henceprovide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNAdecay machinery. Functions by recruiting the CCR4-NOTdeadenylase complex and probably other components of the cytoplasmicRNA decay machinery to the bound ARE-containing mRNAs, and hencepromotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner. Positivelyregulates early adipogenesis by promoting ARE-mediated mRNA decay ofimmediate early genes (IEGs). Plays a role in mature peripheral neuronintegrity by promoting ARE-containing mRNA decay of the transcriptionalrepressor REST mRNA. Plays a role in ovulation and oocyte meioticmaturation by promoting ARE-mediated mRNA decay of the luteinizinghormone receptor LHCGR mRNA. Acts as a negative regulator of erythroidcell differentiation: promotes glucocorticoid-induced self-renewal oferythroid cells by binding mRNAs that are induced or highly expressedduring terminal erythroid differentiation and promotes theirdegradation, preventing erythroid cell differentiation. In associationwith ZFP36L1 maintains quiescence on developing B lymphocytes bypromoting ARE-mediated decay of several mRNAs encoding cell cycleregulators that help B cells progress through the cell cycle, and henceensuring accurate variable-diversity-joining (VDJ) recombinationprocess and functional immune cell formation. Together with ZFP36L1 isalso necessary for thymocyte development and prevention of T-cell acutelymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediatedmRNA decay of the oncogenic transcription factor NOTCH1 mRNA. [1-3]

MSTTLLSAFYDVDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAPSSGFAPGFLRRHSASNLHALAHPAPSPGSCSPKFPGAANGSSCGSAAAGGPTSYGTLKEPSGGGGTALLNKENKFRDRSFSENGDRSQHLLHLQQQQKGGGGSQINSTRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGASGDLRAFGTRDALHLGFPREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSCSSASSCSSSASSCSSASAASTPSGAPTCCASAAAAAAAALLYGTGGAEDLLAPGAPCAACSSASCANNAFAFGPELSSLITPLAIQTHNFAAVAAAAYYRSQQQQQQQGLAPPAQPPAPPSATLPAGAAAPPSPPFSFQLPRRLSDSPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD