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ManualDetails of Host Protein
| Host Protein General Information (ID: PT0728) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Protein Name |
Persulfide dioxygenase ETHE1 (ETHE1)
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Gene Name |
ETHE1
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| Host Species |
Homo sapiens
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Uniprot Entry Name |
ETHE1_HUMAN
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| Protein Families |
Metallo-beta-lactamase superfamily
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| EC Number |
1.13.11.18
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| Subcellular Location |
Cytoplasm Nucleus Mitochondrion matrix
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| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
Sulfur dioxygenase that plays an essential role in hydrogensulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H (2) S) is first oxidized by SQRDL, giving rise to cysteine persulfideresidues. ETHE1 consumes molecular oxygen to catalyze the oxidation ofthe persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolichomeostasis in mitochondria by metabolizing hydrogen sulfide andpreventing the accumulation of supraphysiological H (2) S levels thathave toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus andthe cytoplasm and suppress p53-induced apoptosis by sequestering thetranscription factor RELA/NFKB3 in the cytoplasm and preventing itsaccumulation in the nucleus.
[1-4]
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| Related KEGG Pathway | |||||||||
| Sulfur metabolism | hsa00920 |
Pathway Map 
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| Metabolic pathways | hsa01100 |
Pathway Map 
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| 3D Structure |
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| Function of This Protein During Virus Infection | |||||||||
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| Virus Name | SARS-COV-2 | Protein Function | Anti-viral | [5] | |||||
| Infected Tissue | Lung | Infection Time | 7-9 Days | ||||||
| Infected Cell | Calu-3 Cells (Human epithelial cell line) | Cellosaurus ID | CVCL_0609 | ||||||
| Method Description | To detect the role of host protein ETHE1 in viral infection, ETHE1 protein knockout Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen. | ||||||||
| Results | It is reported that knockout of ETHE1 increases SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Full List of Virus RNA Interacting with This Protien | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| RNA Region: Not Specified Virus Region (hCoV-19/Not Specified Virus Strain ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[6] | |||||||
| Strains Name |
hCoV-19/Not Specified Virus Strain
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| RNA Binding Region |
Not Specified Virus Region
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Huh7 cells (liver carcinoma cell) (CVCL_0336 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Infection Time | 24h | ||||||||
| Interaction Score | log2FC = 3.65372E+14 | ||||||||
| Method Description | RNA antisense purification and quantitative mass spectrometry (RAP-MS); Tandem mass tag (TMT) labelling; liquid chromatography tandem mass spectrometry (LC-MS/MS); Westernblot | ||||||||
