Details of Host Protein
Host Protein General Information (ID: PT0735) | |||||||||
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Protein Name |
PI3-kinase beta (PIK3CB)
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Gene Name |
PIK3CB
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Host Species |
Homo sapiens
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Uniprot Entry Name |
PK3CB_HUMAN
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Protein Families |
PI3/PI4-kinase family
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EC Number |
2.7.1.153
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Subcellular Location |
Cytoplasm Nucleus
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External Link | |||||||||
NCBI Gene ID | |||||||||
Uniprot ID | |||||||||
Ensembl ID | |||||||||
HGNC ID | |||||||||
Function in Host |
Phosphoinositide-3-kinase (PI3K) phosphorylatesphosphatidylinositol derivatives at position 3 of the inositol ring toproduce 3-phosphoinositides. Uses ATP andPtdIns (4, 5) P2 (phosphatidylinositol 4, 5-bisphosphate) to generatephosphatidylinositol 3, 4, 5-trisphosphate (PIP3). PIP3plays a key role by recruiting PH domain-containing proteins to themembrane, including AKT1 and PDPK1, activating signaling cascadesinvolved in cell growth, survival, proliferation, motility andmorphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine1-phosphate, and lysophosphatidic acid. May also act downstreamreceptor tyrosine kinases. Required in different signaling pathways forstable platelet adhesion and aggregation. Plays a role in plateletactivation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activationmotif) -bearing receptors such as GP6. Regulates the strength ofadhesion of ITGA2B/ ITGB3 activated receptors necessary for thecellular transmission of contractile forces. Required for plateletaggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has arole in cell survival. May have a role in cell migration. Involved inthe early stage of autophagosome formation. Modulates the intracellularlevel of PtdIns3P (phosphatidylinositol 3-phosphate) and activatesPIK3C3 kinase activity. May act as a scaffold, independently of itslipid kinase activity to positively regulate autophagy. May have a rolein insulin signaling as scaffolding protein in which the lipid kinaseactivity is not required. May have a kinase-independent function inregulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipidkinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also aprotein kinase activity showing autophosphorylation.
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Related KEGG Pathway | |||||||||
Coronavirus disease - COVID-19 | hsa05171 | Pathway Map | |||||||
Chemokine signaling pathway | hsa04062 | Pathway Map | |||||||
Platelet activation | hsa04611 | Pathway Map | |||||||
Neutrophil extracellular trap formation | hsa04613 | Pathway Map | |||||||
Toll-like receptor signaling pathway | hsa04620 | Pathway Map | |||||||
C-type lectin receptor signaling pathway | hsa04625 | Pathway Map | |||||||
Natural killer cell mediated cytotoxicity | hsa04650 | Pathway Map | |||||||
T cell receptor signaling pathway | hsa04660 | Pathway Map | |||||||
B cell receptor signaling pathway | hsa04662 | Pathway Map | |||||||
Fc epsilon RI signaling pathway | hsa04664 | Pathway Map | |||||||
Fc gamma R-mediated phagocytosis | hsa04666 | Pathway Map | |||||||
Leukocyte transendothelial migration | hsa04670 | Pathway Map | |||||||
Hepatitis C | hsa05160 | Pathway Map | |||||||
Hepatitis B | hsa05161 | Pathway Map | |||||||
Measles | hsa05162 | Pathway Map | |||||||
Human cytomegalovirus infection | hsa05163 | Pathway Map | |||||||
Influenza A | hsa05164 | Pathway Map | |||||||
Human papillomavirus infection | hsa05165 | Pathway Map | |||||||
Human T-cell leukemia virus 1 infection | hsa05166 | Pathway Map | |||||||
Kaposi sarcoma-associated herpesvirus infection | hsa05167 | Pathway Map | |||||||
Herpes simplex virus 1 infection | hsa05168 | Pathway Map | |||||||
Epstein-Barr virus infection | hsa05169 | Pathway Map | |||||||
Human immunodeficiency virus 1 infection | hsa05170 | Pathway Map | |||||||
Viral carcinogenesis | hsa05203 | Pathway Map | |||||||
Bacterial invasion of epithelial cells | hsa05100 | Pathway Map | |||||||
Salmonella infection | hsa05132 | Pathway Map | |||||||
Yersinia infection | hsa05135 | Pathway Map | |||||||
Chagas disease | hsa05142 | Pathway Map | |||||||
Amoebiasis | hsa05146 | Pathway Map | |||||||
3D Structure |
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Function of This Protein During Virus Infection | |||||||||
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Virus Name | SARS-COV-2 | Protein Function | Pro-viral | [6] | |||||
Infected Tissue | Lung | Infection Time | 7-9 Days | ||||||
Infected Cell | Calu-3 Cells (Human epithelial cell line) | Cellosaurus ID | CVCL_0609 | ||||||
Method Description | To detect the role of host protein PIK3CB in viral infection, PIK3CB protein knockout Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen. | ||||||||
Results | It is reported that knockout of PIK3CB leads to the decreased SARS-CoV-2 RNA levels compared with control group. |
Full List of Virus RNA Interacting with This Protien | |||||||||
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RNA Region: 5'-UTR (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [7] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
5'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Infection Cells | HEK293 Cells (Human embryonic kidney cell) (CVCL_0045 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Infection Time | 48 h | ||||||||
Interaction Score | Prot score = 15 | ||||||||
Method Description | RNA-protein interaction detection (RaPID) assay; liquid chromatography with tandem mass spectrometry (LC-MS/MS) |