Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosisand maintenance of tight junction integrity. Class E VPS proteininvolved in concentration and sorting of cargo proteins of themultivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from thelimiting membrane of the endosome. Binds to the phospholipidlysobisphosphatidic acid (LBPA) which is abundant in MVBs internalmembranes. The MVB pathway requires the sequential function of ESCRT-O, -I, -II and -III complexes. The ESCRT machinery alsofunctions in topologically equivalent membrane fission events, such asthe terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to functionat distinct membranes. Required for completion of cytokinesis. May play a role inthe regulation of both apoptosis and cell proliferation. Regulatesexosome biogenesis in concert with SDC1/4 and SDCBP. By interacting with F-actin, PARD3 and TJP1 secures the proper assemblyand positioning of actomyosin-tight junction complex at the apicalsides of adjacent epithelial cells that defines a spatial membranedomain essential for the maintenance of epithelial cell polarity andbarrier. [1-5]

MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSRSVIEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAGTAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPPQQSYYPQQ