Required for pre-mRNA splicing as component of thespliceosome. Core component of thesplicing-dependent multiprotein exon junction complex (EJC) depositedat splice junctions on mRNAs. The EJC is a dynamic structure consistingof core proteins and several peripheral nuclear and cytoplasmicassociated factors that join the complex only transiently either duringEJC assembly or during subsequent mRNA metabolism. The EJC marks theposition of the exon-exon junction in the mature mRNA for the geneexpression machinery and the core components remain bound to splicedmRNAs throughout all stages of mRNA metabolism thereby influencingdownstream processes including nuclear mRNA export, subcellular mRNAlocalization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmicstress granules assembly and by favoring cell recovery followingstress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Bindsspliced mRNA in sequence-independent manner, 20-24 nucleotides upstreamof mRNA exon-exon junctions. Binds poly (G) and poly (U) RNA homomer. [1-4]

MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS