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ManualDetails of Host Protein
| Host Protein General Information (ID: PT0910) | |||||||||
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| Protein Name |
Ras-related protein Rab-2A (RAB2A)
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Gene Name |
RAB2A
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| Host Species |
Homo sapiens
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Uniprot Entry Name |
RAB2A_HUMAN
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| Protein Families |
Small GTPase superfamily
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| Subcellular Location |
Golgi apparatus membrane; Endoplasmic reticulum membrane
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| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
The small GTPases Rab are key regulators of intracellularmembrane trafficking, from the formation of transport vesicles to theirfusion with membranes. Rabs cycle between active GTP-bound and inactiveGDP-bound states. In their active state, drive transport of vesicularcarriers from donor organelles to acceptor organelles to regulate themembrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to theGolgi complex. Regulates the compacted morphology of the Golgi.
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| Related KEGG Pathway | |||||||||
| AMPK signaling pathway | hsa04152 |
Pathway Map 
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| 3D Structure |
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| Function of This Protein During Virus Infection | |||||||||
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| Virus Name | HCoV-229E | Protein Function | Pro-viral | [1] | |||||
| Infected Tissue | Liver | Infection Time | 24 h | ||||||
| Infected Cell | Huh-7.5 Cells (Human hepatocellular carcinoma cells) | Cellosaurus ID | CVCL_7927 | ||||||
| Method Description | To detect the role of host protein RAB2A in viral infection, RAB2A protein knockout Huh-7.5 Cells were infected with HCoV-229E for 24 , and the effects on infection was detected through qRT-PCR. | ||||||||
| Results | It is reported that knockdown of RAB2A leads to the reduced SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Virus Name | HCoV-NL63 | Protein Function | Pro-viral | [1] | |||||
| Infected Tissue | Liver | Infection Time | 24 h | ||||||
| Infected Cell | Huh-7.5 Cells (Human hepatocellular carcinoma cells) | Cellosaurus ID | CVCL_7927 | ||||||
| Method Description | To detect the role of host protein RAB2A in viral infection, RAB2A protein knockout Huh-7.5 Cells were infected with HCoV-NL63 for 24 , and the effects on infection was detected through qRT-PCR. | ||||||||
| Results | It is reported that knockdown of RAB2A leads to the reduced SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Virus Name | HCoV-OC43 | Protein Function | Pro-viral | [1] | |||||
| Infected Tissue | Liver | Infection Time | 24 h | ||||||
| Infected Cell | Huh-7.5 Cells (Human hepatocellular carcinoma cells) | Cellosaurus ID | CVCL_7927 | ||||||
| Method Description | To detect the role of host protein RAB2A in viral infection, RAB2A protein knockout Huh-7.5 Cells were infected with HCoV-OC43 for 24 , and the effects on infection was detected through qRT-PCR. | ||||||||
| Results | It is reported that knockdown of RAB2A leads to the reduced SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Full List of Virus RNA Interacting with This Protien | |||||||||
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| RNA Region: Not Specified Virus Region (hCoV-19/USA/WA1/2020 ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[2] | |||||||
| Strains Name |
hCoV-19/USA/WA1/2020
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| Strains Family |
Alpha (B.1.1.7)
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| RNA Binding Region |
Not Specified Virus Region
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Huh7.5 cells (Hepatocyte derived cellular carcinoma cell) (CVCL_7927 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Infection Time | 48 h | ||||||||
| Interaction Score | FDR ≤ 0.05 | ||||||||
| Method Description | comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS) | ||||||||
