Details of Host Protein

KEGG: hsa04666 Pathway Download ×

KEGG: hsa05163 Pathway Download ×

KEGG: hsa05165 Pathway Download ×

KEGG: hsa05170 Pathway Download ×

KEGG: hsa05131 Pathway Download ×

KEGG: hsa04012 Pathway Download ×

KEGG: hsa04066 Pathway Download ×

KEGG: hsa04140 Pathway Download ×

Host Protein General Information (ID: PT0937)
Protein Name	Ribosomal protein S6 kinase beta-2 (RPS6KB2)	Gene Name	RPS6KB2
Host Species	Homo sapiens	Uniprot Entry Name	KS6B2_HUMAN
Protein Families	Protein kinase superfamily
EC Number	2.7.11.1
Subcellular Location	Cytoplasm
External Link
	NCBI Gene ID	6199
	Uniprot ID	Q9UBS0
	Ensembl ID	ENSG00000133710
	HGNC ID	HGNC:10437
Function in Host	Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling inresponse to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathwayregulated by MEAK7. Click to Show/Hide
Related KEGG Pathway
	Fc gamma R-mediated phagocytosis	hsa04666		Pathway Map
	Human cytomegalovirus infection	hsa05163		Pathway Map
	Human papillomavirus infection	hsa05165		Pathway Map
	Human immunodeficiency virus 1 infection	hsa05170		Pathway Map
	Shigellosis	hsa05131		Pathway Map
	ErbB signaling pathway	hsa04012		Pathway Map
	HIF-1 signaling pathway	hsa04066		Pathway Map
	Autophagy - animal	hsa04140		Pathway Map
3D Structure	AlphaFold ID: Q9UBS0 2D PNG Download mmCIF File Download PDB File Download

Function of This Protein During Virus Infection
Virus Name	SARS-COV-2	Protein Function	Pro-viral	[1]
Infected Tissue	Lung	Infection Time	7-9 Days
Infected Cell	Calu-3 Cells (Human epithelial cell line)	Cellosaurus ID	CVCL_0609
Method Description	To detect the role of host protein RPS6KB2 in viral infection, RPS6KB2 protein knockout Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen.
Results	It is reported that knockout of RPS6KB2 leads to the decreased SARS-CoV-2 RNA levels compared with control group.

Full List of Virus RNA Interacting with This Protien
*RNA Region: 3'-UTR (hCoV-19/Wuhan-Hu-1/2019 )*
RNA Region Details	RNA Info Click to show the detail information of this RNA binding region	[2]
Strains Name	hCoV-19/Wuhan-Hu-1/2019
Strains Family	Beta (B.1.351)
RNA Binding Region	3'-UTR
Virus Name	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Infection Cells	HEK293 Cells (Human embryonic kidney cell) (CVCL_0045 )
Cell Originated Tissue	Liver
Infection Time	48 h
Interaction Score	Prot score = 24
Method Description	RNA-protein interaction detection (RaPID) assay; liquid chromatography with tandem mass spectrometry (LC-MS/MS)

Differential Gene Expression During SARS-COV-2 Infection

GEO Accession: GSE152641

Sample Type: Blood

Samples Details: Healthy Control: 24; COVID-19: 62

Platform: GPL24676 Illumina NovaSeq 6000

PNG Download

GEO Accession: GSE162835

Sample Type: Nasopharyngeal Swabs

Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3

Platform: GPL24676 Illumina NovaSeq 6000

PNG Download

GEO Accession: GSE175779

Sample Type: Human Bronchial Epithelial Cells

Samples Details: Healthy Control: 4 (0, 24, 48, 72 and 96 h); COVID-19: 4 (24, 48, 72 and 96 h)

Platform: GPL18573 Illumina NextSeq 500

PNG Download

Protein Phosphorylation after Virus Infection
S423 [3] PNG Download
Y235 [3] PNG Download

Potential Drug(s) that Targets This Protein
Drug Name																									DrunkBank ID																				Pubchem ID																				TTD ID																									REF
Triparanol																									.																				46205871																				.																									[4]

Protein Sequence Information
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR Click to Show/Hide

References
1	Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2. Nat Commun. 2022 Apr 25;13(1):2237.
2	RNA-Protein Interaction Analysis of SARS-CoV-2 5 and 3 Untranslated Regions Reveals a Role of Lysosome-Associated Membrane Protein-2a during Viral Infection. mSystems. 2021 Aug 31;6(4):e0064321.
3	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.
4	The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Aug 6;182(3):685-712.e19.