Filament-forming cytoskeletal GTPase. Forms a filamentousstructure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at thesperm annulus which is required for the structural integrity andmotility of the sperm tail during postmeiotic differentiation. Required for normal organization of the actincytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thusfacilitating efficient vesicle transport, and by impeding MAP4 bindingto tubulin. Required for the progression through mitosis. Forms ascaffold at the midplane of the mitotic splindle required to maintainCENPE localization at kinetochores and consequently chromosomecongression. During anaphase, may be required for chromosomesegregation and spindle elongation. Plays a role in ciliogenesis andcollective cell movements. In cilia, required for the integrity of thediffusion barrier at the base of the primary cilium that preventsdiffusion of transmembrane proteins between the cilia and plasmamembranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. Mayplay a role in the internalization of 2 intracellular microbialpathogens, Listeria monocytogenes and Shigella flexneri. [1-5]

MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERVIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKRGGRKVENEDMNKDQILLEKEAELRRMQEMIARMQAQMQMQMQGGDGDGGALGHHV