Details of Host Protein

KEGG: hsa05160 Pathway Download ×

KEGG: hsa05165 Pathway Download ×

KEGG: hsa03015 Pathway Download ×

KEGG: hsa05142 Pathway Download ×

KEGG: hsa04071 Pathway Download ×

KEGG: hsa04114 Pathway Download ×

KEGG: hsa04151 Pathway Download ×

KEGG: hsa04152 Pathway Download ×

KEGG: hsa04350 Pathway Download ×

KEGG: hsa04390 Pathway Download ×

KEGG: hsa04530 Pathway Download ×

KEGG: hsa04261 Pathway Download ×

KEGG: hsa04730 Pathway Download ×

Host Protein General Information (ID: PT1035)
Protein Name	PP2A subunit A isoform PR65-beta (MYBBP1A)	Gene Name	PPP2R1B
Host Species	Homo sapiens	Uniprot Entry Name	2AAB_HUMAN
Protein Families	Phosphatase 2A regulatory subunit A family
External Link
	NCBI Gene ID	5519
	Uniprot ID	P30154
	Ensembl ID	ENSG00000132382
	HGNC ID	HGNC:9303
Function in Host	The PR65 subunit of protein phosphatase 2A serves as ascaffolding molecule to coordinate the assembly of the catalyticsubunit and a variable regulatory B subunit. Click to Show/Hide
Related KEGG Pathway
	Hepatitis C	hsa05160		Pathway Map
	Human papillomavirus infection	hsa05165		Pathway Map
	mRNA surveillance pathway	hsa03015		Pathway Map
	Chagas disease	hsa05142		Pathway Map
	Sphingolipid signaling pathway	hsa04071		Pathway Map
	Oocyte meiosis	hsa04114		Pathway Map
	PI3K-Akt signaling pathway	hsa04151		Pathway Map
	AMPK signaling pathway	hsa04152		Pathway Map
	TGF-beta signaling pathway	hsa04350		Pathway Map
	Hippo signaling pathway	hsa04390		Pathway Map
	Tight junction	hsa04530		Pathway Map
	Adrenergic signaling in cardiomyocytes	hsa04261		Pathway Map
	Long-term depression	hsa04730		Pathway Map
3D Structure	AlphaFold ID: P30154 2D PNG Download mmCIF File Download PDB File Download

Function of This Protein During Virus Infection
Virus Name	SARS-COV-2	Protein Function	Pro-viral	[1]
Infected Tissue	Lung	Infection Time	7-9 Days
Infected Cell	Calu-3 Cells (Human epithelial cell line)	Cellosaurus ID	CVCL_0609
Method Description	To detect the role of host protein PPP2R1B in viral infection, PPP2R1B protein knockout Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen.
Results	It is reported that knockout of PPP2R1B leads to the decreased SARS-CoV-2 RNA levels compared with control group.

Full List of Virus RNA Interacting with This Protien
*RNA Region: 5'-UTR (hCoV-19/Wuhan-Hu-1/2019 )*
RNA Region Details	RNA Info Click to show the detail information of this RNA binding region	[2]
Strains Name	hCoV-19/Wuhan-Hu-1/2019
Strains Family	Beta (B.1.351)
RNA Binding Region	5'-UTR
Virus Name	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Infection Cells	HEK293 Cells (Human embryonic kidney cell) (CVCL_0045 )
Cell Originated Tissue	Liver
Infection Time	48 h
Interaction Score	Prot score = 27
Method Description	RNA-protein interaction detection (RaPID) assay; liquid chromatography with tandem mass spectrometry (LC-MS/MS)

Differential Gene Expression During SARS-COV-2 Infection

GEO Accession: GSE152641

Sample Type: Blood

Samples Details: Healthy Control: 24; COVID-19: 62

Platform: GPL24676 Illumina NovaSeq 6000

PNG Download

GEO Accession: GSE162835

Sample Type: Nasopharyngeal Swabs

Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3

Platform: GPL24676 Illumina NovaSeq 6000

PNG Download

GEO Accession: GSE175779

Sample Type: Human Bronchial Epithelial Cells

Samples Details: Healthy Control: 4 (0, 24, 48, 72 and 96 h); COVID-19: 4 (24, 48, 72 and 96 h)

Platform: GPL18573 Illumina NextSeq 500

PNG Download

Protein Sequence Information
MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLALA Click to Show/Hide

References
1	Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2. Nat Commun. 2022 Apr 25;13(1):2237.
2	RNA-Protein Interaction Analysis of SARS-CoV-2 5 and 3 Untranslated Regions Reveals a Role of Lysosome-Associated Membrane Protein-2a during Viral Infection. mSystems. 2021 Aug 31;6(4):e0064321.