Contributes to the organization of the actin cytoskeleton andcell shape. Plays a role in the formation oflamellipodia and in cell migration. Plays a role in the regulation ofneuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in theregulation of neuronal spine density. Plays a role inthe invasiveness of cancer cells, and the formation of metastases. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates corticalactin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P) -mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport andendocytosis, and in modulating the levels of potassium channels presentat the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Requiredfor stabilization of KCNH1 channels at the cell membrane. [1-3]

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