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ManualDetails of Host Protein
| Host Protein General Information (ID: PT1101) | |||||||||
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| Protein Name |
SREBP transcription factor 2 (SREBF2)
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Gene Name |
SREBF2
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| Host Species |
Homo sapiens
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Uniprot Entry Name |
SRBP2_HUMAN
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| Protein Families |
SREBP family
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| Subcellular Location |
Golgi apparatus; Endoplasmic reticulum
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| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
[Sterol regulatory element-binding protein 2]: Precursor ofthe transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulummembrane. Low sterol concentrations promoteprocessing of this form, releasing the transcription factor form thattranslocates into the nucleus and activates transcription of genesinvolved in cholesterol biosynthesis.
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| 3D Structure |
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| Function of This Protein During Virus Infection | |||||||||
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| Virus Name | SARS-COV-2 | Protein Function | Pro-viral | [1] | |||||
| Infected Tissue | Lung | Infection Time | 24 h | ||||||
| Infected Cell | Calu-3 cells (Human lung cancer cell line) | Cellosaurus ID | CVCL_0609 | ||||||
| Method Description | To detect the role of host protein SREBF2 in viral infection, SREBF2 protein knockout Calu-3 cells were infected with SARS-COV-2 for 24 h , and the effects on infection was detected through qRT-PCR. | ||||||||
| Results | It is reported that Knockdown of SREBF2 leads to the reduced SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Full List of Virus RNA Interacting with This Protien | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| RNA Region: 5'-UTR (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[2] | |||||||
| Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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| Strains Family |
Beta (B.1.351)
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| RNA Binding Region |
5'-UTR
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | HEK293 Cells (Human embryonic kidney cell) (CVCL_0045 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Infection Time | 48 h | ||||||||
| Interaction Score | Prot score = 23 | ||||||||
| Method Description | RNA-protein interaction detection (RaPID) assay; liquid chromatography with tandem mass spectrometry (LC-MS/MS) | ||||||||
