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ManualDetails of Host Protein
| Host Protein General Information (ID: PT1141) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Protein Name |
Titin (TTN)
|
Gene Name |
TTN
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| Host Species |
Homo sapiens
|
Uniprot Entry Name |
TITIN_HUMAN
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| Protein Families |
Protein kinase superfamily
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| EC Number |
2.7.11.1
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| Subcellular Location |
Cytoplasm Nucleus
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| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
Key component in the assembly and functioning of vertebratestriated muscles. By providing connections at the level of individualmicrofilaments, it contributes to the fine balance of forces betweenthe two halves of the sarcomere. The size and extensibility of thecross-links are the main determinants of sarcomere extensibilityproperties of muscle. In non-muscle cells, seems to play a role inchromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or bothduring interphase.
[1]
Click to Show/Hide
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| Related KEGG Pathway | |||||||||
| Hypertrophic cardiomyopathy | hsa05410 |
Pathway Map 
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| Dilated cardiomyopathy | hsa05414 |
Pathway Map 
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| 3D Structure |
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| Full List of Virus RNA Interacting with This Protien | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| RNA Region: Not Specified Virus Region (hCoV-19/Not Specified Virus Strain ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
|
[2] | |||||||
| Strains Name |
hCoV-19/Not Specified Virus Strain
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| RNA Binding Region |
Not Specified Virus Region
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Huh7 cells (liver carcinoma cell) (CVCL_0336 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Infection Time | 24h | ||||||||
| Interaction Score | log2FC = 2.70824E+14 | ||||||||
| Method Description | RNA antisense purification and quantitative mass spectrometry (RAP-MS); Tandem mass tag (TMT) labelling; liquid chromatography tandem mass spectrometry (LC-MS/MS); Westernblot | ||||||||
