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ManualDetails of Host Protein
| Host Protein General Information (ID: PT1169) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Protein Name |
Transportin-2 (TNPO2)
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Gene Name |
TNPO2
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| Host Species |
Homo sapiens
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Uniprot Entry Name |
TNPO2_HUMAN
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| Protein Families |
Importin beta family
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| Subcellular Location |
Cytoplasm Nucleus
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| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
Probably functions in nuclear protein import as nucleartransport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC) throughbinding to nucleoporin and the complex is subsequently translocatedthrough the pore by an energy requiring, Ran-dependent mechanism. Atthe nucleoplasmic side of the NPC, Ran binds to the importin, theimportin/substrate complex dissociates and importin is re-exported fromthe nucleus to the cytoplasm where GTP hydrolysis releases Ran. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ran betweenthe cytoplasm and nucleus.
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| Related KEGG Pathway | |||||||||
| Nucleocytoplasmic transport | hsa03013 |
Pathway Map 
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| 3D Structure |
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| Function of This Protein During Virus Infection | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Virus Name | SARS-COV-2 | Protein Function | Anti-viral | [1] | |||||
| Infected Tissue | Lung | Infection Time | 7-9 Days | ||||||
| Infected Cell | Calu-3 Cells (Human epithelial cell line) | Cellosaurus ID | CVCL_0609 | ||||||
| Method Description | To detect the role of host protein TNPO2 in viral infection, TNPO2 protein knockdown Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen. | ||||||||
| Results | It is reported that knockout of TNPO2 increases SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Full List of Virus RNA Interacting with This Protien | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| RNA Region: Not Specified Virus Region (hCoV-19/England/02/2020 ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[2] | |||||||
| Strains Name |
hCoV-19/England/02/2020
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| Strains Family |
Beta (B.1.351)
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| RNA Binding Region |
Not Specified Virus Region
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Calu-3 cells (Human lung cancer cell) (CVCL_0609 ) | ||||||||
| Cell Originated Tissue | Lung | ||||||||
| Infection Time | 24 h | ||||||||
| Interaction Score | P-adjust = 0.072 | ||||||||
| Method Description | UV protein-RNA crosslinking; RNA interactome capture (cRIC); RNA antisense purification coupled with mass spectrometry (RAP-MS) | ||||||||
