Home
Search 
Browse 
Download
ManualDetails of Host Protein
| Host Protein General Information (ID: PT1179) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Protein Name |
tRNA(m1A58)MTase subunit (TRMT61A)
|
Gene Name |
TRMT61A
|
||||||
| Host Species |
Homo sapiens
|
Uniprot Entry Name |
TRM61_HUMAN
|
||||||
| Protein Families |
Class I-like SAM-binding methyltransferase superfamily
|
||||||||
| EC Number |
2.1.1.22.; 2.1.1.-
|
||||||||
| Subcellular Location |
Nucleus
|
||||||||
| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
Catalytic subunit of tRNA (adenine-N (1) -) -methyltransferase, which catalyzes the formation of N (1) -methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalyticsubunit of mRNA N (1) -methyltransferase complex, which mediatesmethylation of adenosine residues at the N (1) position of a smallsubset of mRNAs: N (1) methylation takes place in tRNA T-loop-likestructures of mRNAs and is only present at low stoichiometries.
[1-3]
Click to Show/Hide
|
||||||||
| 3D Structure |
|
||||||||
| Function of This Protein During Virus Infection | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Virus Name | SARS-COV-2 | Protein Function | Anti-viral | [4] | |||||
| Infected Tissue | Lung | Infection Time | 7-9 Days | ||||||
| Infected Cell | Calu-3 Cells (Human epithelial cell line) | Cellosaurus ID | CVCL_0609 | ||||||
| Method Description | To detect the role of host protein TRMT61A in viral infection, TRMT61A protein Knockout Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen. | ||||||||
| Results | It is reported that knockout of TRMT61A increases SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Full List of Virus RNA Interacting with This Protien | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| RNA Region: ORF10 (hCoV-19/Not Specified Virus Strain ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
|
[5] | |||||||
| Strains Name |
hCoV-19/Not Specified Virus Strain
|
||||||||
| RNA Binding Region |
ORF10
|
||||||||
| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
|
||||||||
| Infection Cells | Calu-3 cells (Human Lung Cancer Cell) (CVCL_0609 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Interaction Score | P-value < 0.05 | ||||||||
| Method Description | RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) | ||||||||
