Details of Host Protein

 Host Protein General Information (ID: PT1208)
  Protein Name
Glycine-rich protein (GRP)
  Gene Name
LSM4
  Host Species
Homo sapiens
  Uniprot Entry Name
LSM4_HUMAN
  Protein Families
SnRNP Sm proteins family
  Subcellular Location
Nucleus
  External Link
NCBI Gene ID
25804
Uniprot ID
Q9Y4Z0
Ensembl ID
ENSG00000130520
HGNC ID
HGNC:17259
  Function in Host
Plays role in pre-mRNA splicing as component of the U4/U6-U5tri-snRNP complex that is involved in spliceosome assembly, and ascomponent of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically tothe 3'-terminal U-tract of U6 snRNA. [1-2]
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  Related KEGG Pathway
RNA degradation hsa03018            Pathway Map 
Spliceosome hsa03040            Pathway Map 
RNA degradation hsa03018            Pathway Map 
Spliceosome hsa03040            Pathway Map 
  3D Structure
PDB ID: 3JCR 
FASTA   Download
  2D PNG Download  
PDB File Download

 Full List of Virus RNA Interacting with This Protien
            RNA Region: Not Specified Virus Region (hCoV-19/England/02/2020 )
              RNA Region Details RNA Info Click to show the detail information of this RNA binding region [3]
              Strains Name
hCoV-19/England/02/2020
              Strains Family
Beta (B.1.351)
              RNA Binding Region
Not Specified Virus Region
              Virus Name
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
              Infection Cells Calu-3 cells (Human lung cancer cell)  (CVCL_0609 )
              Cell Originated Tissue Lung
              Infection Time 24 h
              Interaction Score P-adjust = 0.061
              Method Description UV protein-RNA crosslinking; RNA interactome capture (cRIC); RNA antisense purification coupled with mass spectrometry (RAP-MS)

Differential Gene Expression During SARS-COV-2 Infection
GEO Accession: GSE152641
Sample Type: Blood
Samples Details: Healthy Control: 24; COVID-19: 62
Platform: GPL24676 Illumina NovaSeq 6000
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GEO Accession: GSE162835
Sample Type: Nasopharyngeal Swabs
Samples Details: COVID-19 (Mild Symptoms): 37; COVID-19 (Moderate Symptoms): 10; COVID-19 (Severe Symptoms): 3
Platform: GPL24676 Illumina NovaSeq 6000
  PNG Download  
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GEO Accession: GSE175779
Sample Type: Human Bronchial Epithelial Cells
Samples Details: Healthy Control: 4 (0, 24, 48, 72 and 96 h); COVID-19: 4 (24, 48, 72 and 96 h)
Platform: GPL18573 Illumina NextSeq 500
  PNG Download  
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Protein Sequence Information
MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ
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References
1 A doughnut-shaped heteromer of human Sm-like proteins binds to the 3 -end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. EMBO J. 1999 Oct 15;18(20):5789-802.
2 Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell. 2017 Aug 10;170(4):701-713.e11.
3 Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection. Mol Cell. 2021 Jul 1;81(13):2851-2867.e7.