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ManualDetails of Host Protein
| Host Protein General Information (ID: PT1228) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Protein Name |
Unconventional myosin-Id (MYO1D)
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Gene Name |
MYO1D
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| Host Species |
Homo sapiens
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Uniprot Entry Name |
MYO1D_HUMAN
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| Protein Families |
TRAFAC class myosin-kinesin ATPase superfamily
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| Subcellular Location |
Endosome; cytoplasm and Cytosol
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| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
Unconventional myosin that functions as actin-based motorprotein with ATPase activity. Plays a role in endosomalprotein trafficking, and especially in the transfer of cargo proteinsfrom early to recycling endosomes. Required for normalplanar cell polarity in ciliated tracheal cells, for normal rotationalpolarity of cilia, and for coordinated, unidirectional ciliary movementin the trachea. Required for normal, polarized cilia organization inbrain ependymal epithelial cells.
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| Related KEGG Pathway | |||||||||
| Pathogenic Escherichia coli infection | hsa05130 |
Pathway Map 
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| Pathogenic Escherichia coli infection | hsa05130 |
Pathway Map
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| 3D Structure |
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| Function of This Protein During Virus Infection | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Virus Name | SARS-COV-2 | Protein Function | Anti-viral | [1] | |||||
| Infected Tissue | Lung | Infection Time | 7-9 Days | ||||||
| Infected Cell | Calu-3 Cells (Human epithelial cell line) | Cellosaurus ID | CVCL_0609 | ||||||
| Method Description | To detect the role of host protein MYO1D in viral infection, MYO1D protein Knockdown Calu-3 Cells were infected with SARS-COV-2 for 7 - 9 Days , and the effects on infection was detected through CRISPR-based genome-wide gene-knockout screen. | ||||||||
| Results | It is reported that knockout of MYO1D increases SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Full List of Virus RNA Interacting with This Protien | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| RNA Region: ORF10 (hCoV-19/Not Specified Virus Strain ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[2] | |||||||
| Strains Name |
hCoV-19/Not Specified Virus Strain
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| RNA Binding Region |
ORF10
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Calu-3 cells (Human Lung Cancer Cell) (CVCL_0609 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Interaction Score | P-value < 0.05 | ||||||||
| Method Description | RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) | ||||||||
