Specifically recognizes and binds N6-methyladenosine (m6A) -containing RNAs, and regulates their stability. M6A is amodification present at internal sites of mRNAs and some non-codingRNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promotingdegradation of m6A-containing mRNAs via interaction with the CCR4-NOTcomplex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2and YTHDF3) share m6A-containing mRNAs targets and act redundantly tomediate mRNA degradation and cellular differentiation. Acts as a negative regulator of typeI interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs. Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification. Can also act as a regulator of mRNA stability incooperation with YTHDF2 by binding to m6A-containing mRNA and promotingtheir degradation. Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated throughback-splicing of pre-mRNAs, a non-canonical splicing process promotedby dsRNA structures across circularizing exons. Promotes formation of phase-separated membraneless compartments, suchas P-bodies or stress granules, by undergoing liquid-liquid phaseseparation upon binding to mRNAs containing multiple m6A-modifiedresidues: polymethylated mRNAs act as a multivalent scaffold for thebinding of YTHDF proteins, juxtaposing their disordered regions andthereby leading to phase separation. The resulting mRNA-YTHDF complexes then partitioninto different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind N1-methyladenosine (m1A) -containing mRNAs: inhibits trophoblast invasion by binding tom1A-methylated transcripts of IGF1R, promoting their degradation. [1-6]

MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTNQSNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQSSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMTSIATNSVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNIGTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGPQPQAQPHQVQPQQQQLQNRWVAPRNRGAGFNQNNGAGSENFGLGVVPVSASPSSVEVHPVLEKLKAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEAMRRERNRNKQ