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ManualDetails of Host Protein
| Host Protein General Information (ID: PT0334) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Protein Name |
GTP-binding protein 1 (DRG-1)
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Gene Name |
DRG1
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| Host Species |
Homo sapiens
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Uniprot Entry Name |
DRG1_HUMAN
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| Protein Families |
TRAFAC class OBG-HflX-like GTPase superfamily
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| EC Number |
3.6.5.-
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| Subcellular Location |
Nucleus Cytoplasm
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| External Link | |||||||||
| NCBI Gene ID | |||||||||
| Uniprot ID | |||||||||
| Ensembl ID | |||||||||
| HGNC ID | |||||||||
| Function in Host |
Catalyzes the conversion of GTP to GDP through hydrolysis ofthe gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated byZC3H15/DFRP1 binding likely by increasing the affinity for thepotassium ions. When hydroxylated at C-3 of 'Lys-22'by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotesmicrotubule polymerization and stability that are required for mitoticspindle assembly during prophase to anaphase transition. GTPaseactivity is not necessary for these microtubule-related functions.
[1-4]
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| 3D Structure |
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| Function of This Protein During Virus Infection | |||||||||
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| Virus Name | SARS-COV-2 | Protein Function | Pro-viral | [5] | |||||
| Infected Tissue | Kidney | Infection Time | 48 h | ||||||
| Infected Cell | vero e6 cells(African green monkey kidny cell) | Cellosaurus ID | CVCL_YZ66 | ||||||
| Method Description | To detect the role of host protein DRG1 in viral infection, DRG1 protein knockout vero e6 cells(African green monkey kidny cell) were infected with SARS-COV-2 for 48 h , and the effects on infection was detected through Kit. | ||||||||
| Results | It is reported that Knockdown of DRG1 leads to the reduced SARS-CoV-2 RNA levels compared with control group. | ||||||||
| Host Protein - Virus RNA Network | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Full List of Virus RNA Interacting with This Protien | |||||||||
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| RNA Region: ORF10 (hCoV-19/Not Specified Virus Strain ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[6] | |||||||
| Strains Name |
hCoV-19/Not Specified Virus Strain
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| RNA Binding Region |
ORF10
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Calu-3 cells (Human Lung Cancer Cell) (CVCL_0609 ) | ||||||||
| Cell Originated Tissue | Liver | ||||||||
| Interaction Score | P-value < 0.05 | ||||||||
| Method Description | RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) | ||||||||
| RNA Region: Not Specified Virus Region (hCoV-19/England/02/2020 ) | |||||||||
| RNA Region Details |
RNA Info
Click to show the detail information of this RNA binding region
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[7] | |||||||
| Strains Name |
hCoV-19/England/02/2020
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| Strains Family |
Beta (B.1.351)
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| RNA Binding Region |
Not Specified Virus Region
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| Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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| Infection Cells | Calu-3 cells (Human lung cancer cell) Calu-3 cells (Human lung cancer cell) (CVCL_0609 ) | ||||||||
| Cell Originated Tissue | Lung | ||||||||
| Infection Time | 24 h | ||||||||
| Interaction Score | P-adjust = 0.004 | ||||||||
| Method Description | UV protein-RNA crosslinking; RNA interactome capture (cRIC); RNA antisense purification coupled with mass spectrometry (RAP-MS) | ||||||||
