Multifunctional ATP-dependent nucleic acid helicase thatunwinds DNA and RNA in a 3' to 5' direction and that plays importantroles in many processes, such as DNA replication, transcriptionalactivation, post-transcriptional RNA regulation, mRNA translation andRNA-mediated gene silencing. Requires a 3'-single-stranded tailas entry site for acid nuclei unwinding activities as well as thebinding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Unwinds numerousnucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partiallycomplementary DNA duplexes or DNA:RNA hybrids, respectively, and alsoDNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes. Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly (A) -containing RNA. Binds also to circular dsDNA ordsRNA of either linear and/or circular forms and stimulates therelaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A. Plays a role in DNA replication at origins ofreplication and cell cycle progression. Plays a roleas a transcriptional coactivator acting as a bridging factor betweenpolymerase II holoenzyme and transcription factors or cofactors, suchas BRCA1, CREBBP, RELA and SMN1. Binds to the CDKN2A promoter. Playsseveral roles in post-transcriptional regulation of gene expression. In cooperation with NUP98, promotespre-mRNA alternative splicing activities of a subset of genes. As component of a large PER complex, is involved in the negativeregulation of 3' transcriptional termination of circadian target genessuch as PER1 and NR1D1 and the control of the circadian rhythms. Acts also as a nuclear resolvase that is able to bind andneutralize harmful massive secondary double-stranded RNA structuresformed by inverted-repeat Alu retrotransposon elements that areinserted and transcribed as parts of genes during the process of genetransposition. Involved in the positive regulation ofnuclear export of constitutive transport element (CTE) -containingunspliced mRNA. Component of the coding region determinant (CRD) -mediated complex thatpromotes cytoplasmic MYC mRNA stability. Plays a rolein mRNA translation. Positively regulates translationof selected mRNAs through its binding to post-transcriptional controlelement (PCE) in the 5'-untranslated region (UTR). Involved with LARP6 in the translation stimulation of type I collagenmRNAs for CO1A1 and CO1A2 through binding of a specific stem-loopstructure in their 5'-UTRs. Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoproteinremodeling during the process of translation. Playsalso a role as a small interfering (siRNA) -loading factor involved inthe RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencingprocess. Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinalinfection. This interaction may mediate NLRP9inflammasome activation and trigger inflammatory response, includingIL18 release and pyroptosis. Finally, mediates theattachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) toactin filaments in the nucleus. [1-6]

MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGPETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIKLQISHEAAACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMIRQISRPSAAGINLMIGSTRYGDGPRPPKMARYDNGSGYRRGGSSYSGGGYGGGYSSGGYGSGGYGGSANSFRAGYGAGVGGGYRGVSRGGFRGNSGGDYRGPSGGYRGSGGFQRGGGRGAYGTGYFGQGRGGGGY