DNA- and RNA-binding protein involved in several cellularprocesses such as nuclear chromatin organization, telomere-lengthregulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation ofinterphase large-scale gene-rich chromatin organization throughchromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localization of thelong non-coding Xist RNA on the inactive chromosome X (Xi) and thesubsequent initiation and maintenance of X-linked transcriptional genesilencing during X-inactivation. Plays a role as a RNApolymerase II (Pol II) holoenzyme transcription regulator. Promotes transcription initiation bydirect association with the core-TFIIH basal transcription factorcomplex for the assembly of a functional pre-initiation complex withPol II in a actin-dependent manner. Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates fromPol II pre-initiation complex prior to productive transcriptionelongation. Positively regulates CBX5-inducedtranscriptional gene silencing and retention of CBX5 in the nucleus. Negatively regulates glucocorticoid-mediatedtranscriptional activation. Key regulator oftranscription initiation and elongation in embryonic stem cells uponleukemia inhibitory factor (LIF) signaling. Involved inthe long non-coding RNA H19-mediated Pol II transcriptional repression. Participates in the circadian regulation of the coreclock component ARNTL/BMAL1 transcription. Plays a rolein the regulation of telomere length. Plays a role asa global pre-mRNA alternative splicing modulator by regulating U2 smallnuclear ribonucleoprotein (snRNP) biogenesis. Plays arole in mRNA stability. Component of the CRD-mediated complex that promotesMYC mRNA stabilization. Enhances the expression ofspecific genes, such as tumor necrosis factor TNFA, by regulating mRNAstability, possibly through binding to the 3'-untranslated region (UTR). Plays a role in mitotic cell cycle regulation. Involved in the formation of stablemitotic spindle microtubules (MTs) attachment to kinetochore, spindleorganization and chromosome congression. Phosphorylation at Ser-59 by PLK1 is required for chromosome alignementand segregation and progression through mitosis. Contributes also to the targeting of AURKA to mitotic spindle MTs. Binds to double- and single-stranded DNA and RNA, poly (A), poly (C) and poly (G) oligoribonucleotides. Bindsto chromatin-associated RNAs (caRNAs). Associateswith chromatin to scaffold/matrix attachment region (S/MAR) elements ina chromatin-associated RNAs (caRNAs) -dependent manner . Binds to the XistRNA. Binds the long non-coding H19 RNA. Binds to SMN1/2 pre-mRNAs at G/U-rich regions. Binds to small nuclear RNAs (snRNAs). Binds to the 3'-UTR of TNFA mRNA. Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA;this binding is direct and bridges the Xist RNA and the inactivechromosome X (Xi). Also negatively regulates embryonicstem cell differentiation upon LIF signaling. Requiredfor embryonic development. Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7Brequired to drive brown and beige fat development and thermogenesis. [1-8]

MSSSPVNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALDDEEAGGRPAMEPGNGSLDLGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGDQMELGEENGAAGAADSGPMEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQPQPPATQQQQPQQQRGAAKEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGKKKAEGGGGGGRPGAPAAGDGKTEQKGGDKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQGQFWGQKPWSQHYHQGYY