Details of Host Protein
Host Protein General Information (ID: PT0768) | |||||||||
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Protein Name |
Polypyrimidine tract-binding protein (PTBP1)
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Gene Name |
PTBP1
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Host Species |
Homo sapiens
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Uniprot Entry Name |
PTBP1_HUMAN
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Subcellular Location |
Nucleus
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External Link | |||||||||
NCBI Gene ID | |||||||||
Uniprot ID | |||||||||
Ensembl ID | |||||||||
HGNC ID | |||||||||
Function in Host |
Plays a role in pre-mRNA splicing and in the regulation ofalternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidinetract of introns. May promote RNA looping when bound to two separatepolypyrimidine tracts in the same pre-mRNA. May promote the binding ofU2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switchingbetween mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR andpromotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 andits role in exon inclusion of CFTR exon 9. Plays arole in the splicing of pyruvate kinase PKM by binding repressively toa polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusionand resulting in exon 10 inclusion and production of the PKM M2 isoform. In case of infection by picornaviruses, binds to theviral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.
[1-8]
Click to Show/Hide
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3D Structure |
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Function of This Protein During Virus Infection | |||||||||
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Virus Name | SARS-COV-2 | Protein Function | Pro-viral | [9] | |||||
Infected Tissue | Lung | Infection Time | 48 h | ||||||
Infected Cell | Calu-3 cells (Human lung cancer cell) | Cellosaurus ID | CVCL_0609 | ||||||
Method Description | To detect the role of host protein PTBP1 in viral infection, PTBP1 protein knockout Calu-3 cells were infected with SARS-COV-2 for 48 h , and the effects on infection was detected through qRT-PCR. | ||||||||
Results | It is reported that knockdown of PTBP1 leads to the reduced SARS-CoV-2 RNA levels compared with control group. |
Host Protein - Virus RNA Network | |||||||||
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Full List of Virus RNA Interacting with This Protien | |||||||||
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RNA Region: 3'-UTR (hCoV-SARS/Manitoba/2003 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [10] | |||||||
Strains Name |
hCoV-SARS/Manitoba/2003
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Strains Family |
Beta
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RNA Binding Region |
3'-UTR
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Virus Name |
Severe acute respiratory syndrome-related coronavirus (HCoV-SARS)
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Interaction Type | Potential binding protein | ||||||||
Infection Cells | HepG2 cells (hepatocellular carcinoma cell line) (CVCL_0027 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Method Description | ENCODE project database; Pysster model; DeepRiPe (Section 3.6; 3.7; 3.8; 3.9); ClustalO (72) algorithm | ||||||||
RNA Region: 3'-UTR (hCov-OC43/VR-759 Quebec/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [10] | |||||||
Strains Name |
hCov-OC43/VR-759 Quebec/2019
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Strains Family |
Beta
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RNA Binding Region |
3'-UTR
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Virus Name |
Human coronavirus OC43 (HCov-OC43)
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Interaction Type | Potential binding protein | ||||||||
Infection Cells | HepG2 cells (hepatocellular carcinoma cell line) HepG2 cells (hepatocellular carcinoma cell line) (CVCL_0027 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Method Description | ENCODE project database; Pysster model; DeepRiPe (Section 3.6; 3.7; 3.8; 3.9); ClustalO (72) algorithm | ||||||||
RNA Region: 3'-UTR (hCov-NL63/Amsterdam/2004 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [10] | |||||||
Strains Name |
hCov-NL63/Amsterdam/2004
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Strains Family |
Alpha
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RNA Binding Region |
3'-UTR
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Virus Name |
Human Coronavirus NL63 (HCov-NL63)
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Interaction Type | Potential binding protein | ||||||||
Infection Cells | HepG2 cells (hepatocellular carcinoma cell line) HepG2 cells (hepatocellular carcinoma cell line) (CVCL_0027 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Method Description | ENCODE project database; Pysster model; DeepRiPe (Section 3.6; 3.7; 3.8; 3.9); ClustalO (72) algorithm | ||||||||
RNA Region: 3'-UTR (hCov-MERS/Jeddah/2012 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [10] | |||||||
Strains Name |
hCov-MERS/Jeddah/2012
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Strains Family |
Beta
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RNA Binding Region |
3'-UTR
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Virus Name |
Middle East respiratory syndrome-related coronavirus (HCov-MERS)
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Interaction Type | Potential binding protein | ||||||||
Infection Cells | HepG2 cells (hepatocellular carcinoma cell line) HepG2 cells (hepatocellular carcinoma cell line) (CVCL_0027 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Method Description | ENCODE project database; Pysster model; DeepRiPe (Section 3.6; 3.7; 3.8; 3.9); ClustalO (72) algorithm | ||||||||
RNA Region: 3'-UTR (hCoV-HKU1/Hong Kong/2004 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [10] | |||||||
Strains Name |
hCoV-HKU1/Hong Kong/2004
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Strains Family |
Beta
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RNA Binding Region |
3'-UTR
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Virus Name |
Human coronavirus HKU1 (HCoV-HKU1)
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Interaction Type | Potential binding protein | ||||||||
Infection Cells | HepG2 cells (hepatocellular carcinoma cell line) HepG2 cells (hepatocellular carcinoma cell line) (CVCL_0027 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Method Description | ENCODE project database; Pysster model; DeepRiPe (Section 3.6; 3.7; 3.8; 3.9); ClustalO (72) algorithm | ||||||||
RNA Region: 3'-UTR (hCov-229E/Würzburg/2000 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [10] | |||||||
Strains Name |
hCov-229E/Würzburg/2000
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Strains Family |
Alpha
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RNA Binding Region |
3'-UTR
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Virus Name |
Human coronavirus 229E (HCov-229E)
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Interaction Type | Potential binding protein | ||||||||
Infection Cells | HepG2 cells (hepatocellular carcinoma cell line) HepG2 cells (hepatocellular carcinoma cell line) (CVCL_0027 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Method Description | ENCODE project database; Pysster model; DeepRiPe (Section 3.6; 3.7; 3.8; 3.9); ClustalO (72) algorithm | ||||||||
RNA Region: 3'-UTR (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
3'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: 3'-UTR (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [10] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
3'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Infection Cells | HepG2 cells (hepatocellular carcinoma cell line) HepG2 cells (hepatocellular carcinoma cell line) (CVCL_0027 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Method Description | ENCODE project database; Pysster model; DeepRiPe (Section 3.6; 3.7; 3.8; 3.9); ClustalO (72) algorithm | ||||||||
RNA Region: 3'-UTR (hCoV-19/Not Specified Virus Strain ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [12] | |||||||
Strains Name |
hCoV-19/Not Specified Virus Strain
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RNA Binding Region |
3'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Infection Cells | Huh7 cells (human liver cell line); Calu-3 cells (human lung cancer cell line) Huh7 cells (human liver cell line); Calu-3 cells (human lung cancer cell line) (CVCL_0336;CVCL_0609 ) | ||||||||
Cell Originated Tissue | Liver; Lung | ||||||||
Interaction Score | P-value < 0.05 | ||||||||
Method Description | RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) | ||||||||
RNA Region: 3'-UTR (hCoV-19/IPBCAMS-YL01/2020 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [13] | |||||||
Strains Name |
hCoV-19/IPBCAMS-YL01/2020
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
3'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Infection Cells | Huh7.5.1 cells (Hepatocyte derived cellular carcinoma cell) Huh7.5.1 cells (Hepatocyte derived cellular carcinoma cell) (CVCL_E049 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Infection Time | 30 h | ||||||||
Interaction Score | Affinity = 0.963 | ||||||||
Method Description | PrismNet; pull-down western (STAR methods); Mass spectrometry | ||||||||
RNA Region: 3'-UTR (hCoV-19/IPBCAMS-YL01/2020 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [14], [15], [16] | |||||||
Strains Name |
hCoV-19/IPBCAMS-YL01/2020
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
3'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | known to be direct binder | ||||||||
Interaction Binding Type | Single stranded RNA binding | ||||||||
Infection Cells | Huh7.5.1 cells (Hepatocyte derived cellular carcinoma cell) Huh7.5.1 cells (Hepatocyte derived cellular carcinoma cell) (CVCL_E049 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Infection Time | 30 h | ||||||||
Interaction Score | MIST = 0.685520813 | ||||||||
Method Description | comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS) | ||||||||
RNA Region: 5'-UTR (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
5'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: 5'-UTR (hCoV-19/South Korea/KCDC03/2020 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [9] | |||||||
Strains Name |
hCoV-19/South Korea/KCDC03/2020
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Strains Family |
Alpha (B.1.1.7)
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RNA Binding Region |
5'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Directly bind to SARS-CoV-23 RNA's 5' UTR region | ||||||||
Infection Cells | Vero cells (epithelial kidney cell) Vero cells (epithelial kidney cell) (CVCL_0059 ) | ||||||||
Cell Originated Tissue | kidney | ||||||||
Infection Time | 24 h | ||||||||
Interaction Score | P-adjust < 0.05 | ||||||||
Method Description | Modified RNA antisense purification coupled with mass spectrometry (RAP-MS); label-free quantification (LFQ); liquid chromatography with tandem mass spectrometry (LC-MS/MS) | ||||||||
RNA Region: 5'-UTR (hCoV-19/Not Specified Virus Strain ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [12] | |||||||
Strains Name |
hCoV-19/Not Specified Virus Strain
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RNA Binding Region |
5'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Infection Cells | Huh7 cells (human liver cell line); Calu-3 cells (human lung cancer cell line) Huh7 cells (human liver cell line); Calu-3 cells (human lung cancer cell line) (CVCL_0336;CVCL_0609 ) | ||||||||
Cell Originated Tissue | Liver; Lung | ||||||||
Interaction Score | P-value < 0.05 | ||||||||
Method Description | RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) | ||||||||
RNA Region: 5'-UTR (hCoV-19/IPBCAMS-YL01/2020 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [13] | |||||||
Strains Name |
hCoV-19/IPBCAMS-YL01/2020
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
5'-UTR
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Infection Cells | Huh7.5.1 cells (Hepatocyte derived cellular carcinoma cell) Huh7.5.1 cells (Hepatocyte derived cellular carcinoma cell) (CVCL_E049 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Infection Time | 30 h | ||||||||
Interaction Score | Affinity = 0.899 | ||||||||
Method Description | PrismNet; pull-down western (STAR methods); Mass spectrometry | ||||||||
RNA Region: ORF10 (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
ORF10
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: ORF10 (hCoV-19/Not Specified Virus Strain ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [12] | |||||||
Strains Name |
hCoV-19/Not Specified Virus Strain
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
ORF10
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Infection Cells | Huh7 cells (human liver cell line); Calu-3 cells (human lung cancer cell line) Huh7 cells (human liver cell line); Calu-3 cells (human lung cancer cell line) (CVCL_0336;CVCL_0609 ) | ||||||||
Cell Originated Tissue | Liver; Lung | ||||||||
Interaction Score | P-value < 0.05 | ||||||||
Method Description | RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) | ||||||||
RNA Region: 5'-UTR-L (hCoV-19/Not Specified Virus Strain ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [12] | |||||||
Strains Name |
hCoV-19/Not Specified Virus Strain
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RNA Binding Region |
5'-UTR-L
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Infection Cells | Huh7 cells (human liver cell line); Calu-3 cells (human lung cancer cell line) Huh7 cells (human liver cell line); Calu-3 cells (human lung cancer cell line) (CVCL_0336;CVCL_0609 ) | ||||||||
Cell Originated Tissue | Liver; Lung | ||||||||
Interaction Score | P-value < 0.05 | ||||||||
Method Description | RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) | ||||||||
RNA Region: ORF1ab (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
ORF1ab
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: ORF3a (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
ORF3a
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: ORF6 (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
ORF6
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: ORF7a (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
ORF7a
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: ORF7b (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
ORF7b
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: ORF8 (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
ORF8
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: E region (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
E region
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: M region (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
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Strains Family |
Beta (B.1.351)
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RNA Binding Region |
M region
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: N region (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
|
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Strains Family |
Beta (B.1.351)
|
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RNA Binding Region |
N region
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
|
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: S region (hCoV-19/Wuhan-Hu-1/2019 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [11] | |||||||
Strains Name |
hCoV-19/Wuhan-Hu-1/2019
|
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Strains Family |
Beta (B.1.351)
|
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RNA Binding Region |
S region
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Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
|
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Interaction Type | Potential binding protein | ||||||||
Method Description | ATtRACT Database; Position Weight Matrices (PWMs); TFBSTools R package | ||||||||
RNA Region: Not Specified Virus Region (hCoV-19/USA/WA1/2020 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [17] | |||||||
Strains Name |
hCoV-19/USA/WA1/2020
|
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Strains Family |
Alpha (B.1.1.7)
|
||||||||
RNA Binding Region |
Not Specified Virus Region
|
||||||||
Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
|
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Infection Cells | Huh7.5 cells (Hepatocyte derived cellular carcinoma cell) Huh7.5 cells (Hepatocyte derived cellular carcinoma cell) (CVCL_7927 ) | ||||||||
Cell Originated Tissue | Liver | ||||||||
Infection Time | 48 h | ||||||||
Interaction Score | FDR ≤ 0.05 | ||||||||
Method Description | comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS) | ||||||||
RNA Region: Not Specified Virus Region (hCoV-19/France/IDF-220-95/2020 ) | |||||||||
RNA Region Details | RNA Info Click to show the detail information of this RNA binding region | [18] | |||||||
Strains Name |
hCoV-19/France/IDF-220-95/2020
|
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RNA Binding Region |
Not Specified Virus Region
|
||||||||
Virus Name |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
|
||||||||
Interaction Type | Direct interaction | ||||||||
Infection Cells | HEK293 Cells (Human embryonic kidney cell) HEK293 Cells (Human embryonic kidney cell) (CVCL_0045 ) | ||||||||
Cell Originated Tissue | Kidney | ||||||||
Infection Time | 48 h | ||||||||
Interaction Score | SAINT score ≥ 0.79 | ||||||||
Method Description | comprehensive identification of RNA-binding proteins by massspectrometry (ChIRP-MS) |
Differential Gene Expression During SARS-COV-2 Infection | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Protein Phosphorylation after Virus Infection | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S141
[19] |
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S141
[20] |
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S433
[20] |
Potential Drug(s) that Targets This Protein | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Drug Name | DrunkBank ID | Pubchem ID | TTD ID | REF | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DISULFIRAM | DB00822 | 3117 | D0X5SD | [13] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Triparanol | . | 3213 | D00DNY | [13] |
Protein Sequence Information |
MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGLSVPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGNQAQLAMSHLNGHKLHGKPIRITLSKHQNVQLPREGQEDQGLTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEEDLKVLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIDLHNHDLGENHHLRVSFSKSTI
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