Involved in translation as a component of the 40S smallribosomal subunit. Has endonuclease activity and playsa role in repair of damaged DNA. Cleavesphosphodiester bonds of DNAs containing altered bases with broadspecificity and cleaves supercoiled DNA more efficiently than relaxedDNA. Displays high binding affinity for 7, 8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygenspecies (ROS). Has also been shown to bind withsimilar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiesterbackbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNArepair in cells exposed to hydrogen peroxide. Plays arole in regulating transcription as part of the NF-kappa-B p65-p50complex where it binds to the RELA/p65 subunit, enhances binding of thecomplex to DNA and promotes transcription of target genes. Represses its own translation by binding to itscognate mRNA. Binds to and protects TP53/p53 fromMDM2-mediated ubiquitination. Involved in spindleformation and chromosome movement during mitosis by regulatingmicrotubule polymerization. Involved in induction ofapoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcriptionfactor and acting synergistically with it to up-regulate pro-apoptoticproteins BCL2L11/BIM and HRK/Dp5. Interacts withTRADD following exposure to UV radiation and induces apoptosis bycaspase-dependent JNK activation. [1-3]

MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPVPTA